{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:30:29Z","timestamp":1787016629930,"version":"build-2736575974"},"reference-count":70,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2025,7,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Competition for resources is one of the major drivers for evolution and retention of new traits in microbial communities. Quorum sensing-dependent traits of the opportunistic human pathogen\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      allow it to survive and thrive in the presence of other microbes. Here, we report a unique mechanism that\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      employs specifically against\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      to displace it on solid surfaces. Interestingly,\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      employs neither proteases nor toxic secondary metabolites against\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      . Rhamnolipid biosurfactant under the control of the RhlR quorum sensing system appears to be the primary factor required to displace\n                      <jats:italic toggle=\"yes\">Klebsiella<\/jats:italic>\n                      effectively. Under conditions of iron limitation, both bacteria produce iron-scavenging molecules, while\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      also produces rhamnolipid biosurfactant, allowing it to push\n                      <jats:italic toggle=\"yes\">Klebsiella<\/jats:italic>\n                      cells away from the substratum. Our study describes a unique quorum and iron-responsive mechanism in\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      to support its own growth during resource competition on a solid surface.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>Competition is common among organisms in nature. Bacteria have been known to deal with their neighbors using toxins and enzymes that kill or disable the latter. Here, we describe a simple, detergent-mediated mechanism that a common bacterium employs against its neighbor to push them away. This only happens in a time of scarcity of iron, an element essential for life, big and small.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.01149-25","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:00:31Z","timestamp":1749632431000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Toroidal displacement of\n                    <i>Klebsiella pneumoniae<\/i>\n                    by\n                    <i>Pseudomonas aeruginosa<\/i>\n                    is a unique mechanism to avoid competition for iron"],"prefix":"10.1128","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3774-6733","authenticated-orcid":false,"given":"Diana","family":"Pradhan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05j873a45","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Developmental Biology & Genetics, Indian Institute of Science","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-0358","authenticated-orcid":false,"given":"Ajay","family":"Tanwar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05j873a45","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Developmental Biology & Genetics, Indian Institute of Science","place":["Bangalore, India"]},{"name":"Division of Moleculer Microbiology, University of Dundee","place":["Dundee, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-6731","authenticated-orcid":true,"given":"Joshua","family":"Wong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/041kmwe10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Life Sciences, Imperial College","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srividhya","family":"Parthasarathi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physics, Indian Institute of Science","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-1363","authenticated-orcid":true,"given":"Gad M.","family":"Frankel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/041kmwe10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Life Sciences, Imperial College","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-5901","authenticated-orcid":true,"given":"Varsha","family":"Singh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05j873a45","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Developmental Biology & Genetics, Indian Institute of Science","place":["Bangalore, India"]},{"name":"Division of Moleculer Microbiology, University of Dundee","place":["Dundee, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2014.53"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.2.554-566.2005"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00106"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17745-9"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2011.10.013"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/28999734"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc10444"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.5.1618"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00472.x"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056846"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06516-7"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-8-43"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13279"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/653053"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00321"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.8.3548-3558.2003"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002489900002"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00521-13"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3ob42416b"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01785"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.21.7351-7361.2005"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.3.1027-1036.2003"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.21.5990-5996.2000"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02033-21"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.02.028"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13904"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-014-0100-x"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.18.5756-5767.1997"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00961-22"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki008"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.100.3.965"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.06644-11"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.2.518-523.1996"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00098-16"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01586.x"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004279"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36747"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2007.01286.x"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01906-16"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00078-15"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-020518-120033"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01601-09"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26154-0"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01378-06"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00043-07"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53203-8"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008783"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000860"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12650-2"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2003981"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-011-9494-7"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.4.1834-1839.2000"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00125-18"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04743.x"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016433"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01801.x"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020888"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07436.x"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090110-102851"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00414599"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.16373"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511100103"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009376"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11756-y"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/evo.12183"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(18)68566-7"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.115"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13250"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1006\/plas.1999.1441"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01149-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01149-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T13:06:04Z","timestamp":1752066364000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01149-25"}},"subtitle":[],"editor":[{"given":"Kalai","family":"Mathee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Lars E. P.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":70,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,9]]}},"alternative-id":["10.1128\/mbio.01149-25"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01149-25","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.21.508880","asserted-by":"object"}]},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01149-25"}}