{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:13:21Z","timestamp":1753881201790,"version":"3.41.2"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Ministry of Economy (Israel) | Israel Innovation Authority","award":["62615, 72670, 75934"],"award-info":[{"award-number":["62615, 72670, 75934"]}]},{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"crossref","award":["1412-414.13\/2017"],"award-info":[{"award-number":["1412-414.13\/2017"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"crossref","award":["ISF Israel-China grant 2554\/18"],"award-info":[{"award-number":["ISF Israel-China grant 2554\/18"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","award":["3-14764"],"award-info":[{"award-number":["3-14764"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"crossref","award":["Moked grant 442-18, 3042\/22, 619\/23"],"award-info":[{"award-number":["Moked grant 442-18, 3042\/22, 619\/23"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Integra Holdings LTD","award":["11-2020-22710"],"award-info":[{"award-number":["11-2020-22710"]}]},{"name":"MOST-DKFZ","award":["grant 3-14931"],"award-info":[{"award-number":["grant 3-14931"]}]},{"name":"Cytovia Therapeutics Holdings","award":["6-2020-22652"],"award-info":[{"award-number":["6-2020-22652"]}]},{"name":"The Rothschild Foundation"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,9,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is an inhibitory receptor expressed by T and natural killer cells. Here, we used TIGIT knockout (KO) mice to demonstrate that mouse TIGIT directly interacts with\n              <jats:italic>Candida albicans<\/jats:italic>\n              . Reduced fungal growth and colonization were observed when TIGIT-KO splenocytes were co-cultured with\n              <jats:italic>C. albicans<\/jats:italic>\n              compared to the wild type (WT). In a systemic candidiasis model, TIGIT-KO mice exhibited improved survival and reduced body weight loss compared to WT mice. Organ-specific fungal burden assessment revealed significantly lower fungal loads in the kidneys, spleen, and lungs of TIGIT-KO mice. Finally, we show that the agglutinin-like sequence proteins ALS6, ALS7, and ALS9 of\n              <jats:italic>C. albicans<\/jats:italic>\n              are ligands for TIGIT and that the absence of these proteins abolishes the TIGIT effect\n              <jats:italic>in vivo<\/jats:italic>\n              . Our results identify the significance of TIGIT in modulating host defense against\n              <jats:italic>C. albicans<\/jats:italic>\n              and highlight the potential therapeutic implications for\n              <jats:italic>C. albicans<\/jats:italic>\n              infections.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              Our results identify the significance of T cell immunoreceptor with immunoglobulin and ITIM domain in modulating host defense against\n              <jats:italic>Candida albicans<\/jats:italic>\n              and highlight the potential therapeutic implications for\n              <jats:italic>C. albicans<\/jats:italic>\n              infections.\n            <\/jats:p>\n          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