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Current strategies are focused on modulating TP53 regulatory proteins. Long noncoding RNAs (lncRNAs) have emerged as important regulators of TP53 as well as modulators of downstream tumor-suppressive transcriptional responses. Unlike many other cancer types, human papillomavirus (HPV)-positive cancer cells retain wild-type TP53 that is rendered dysfunctional by the viral E6 protein. We show that acute expression of the damage-induced long noncoding RNA, DINO, a known TP53 transcriptional target and functional modulator, causes TP53 reactivation in HPV-positive cervical cancer cells. This causes increased vulnerability to standard chemotherapeutics as well as biguanide compounds that cause metabolic stress. Hence, strategies that target DINO may be useful for restoring TP53 tumor suppressor activity in HPV-positive cancers and other tumor types that retain wild-type TP53.<\/jats:p>","DOI":"10.1128\/mbio.01190-20","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T10:17:27Z","timestamp":1592216247000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Expression of the Long Noncoding RNA DINO in Human Papillomavirus-Positive Cervical Cancer Cells Reactivates the Dormant TP53 Tumor Suppressor through ATM\/CHK2 Signaling"],"prefix":"10.1128","volume":"11","author":[{"given":"Surendra","family":"Sharma","sequence":"first","affiliation":[{"name":"Biochemistry Program, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA"},{"name":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Munger","sequence":"additional","affiliation":[{"name":"Biochemistry Program, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA"},{"name":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"4620","article-title":"E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway","volume":"56","author":"Boyer SN","year":"1996","unstructured":"Boyer SN, Wazer DE, Band V. 1996. 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