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We performed dual RNA-seq and metabolomics analyses on wounded and infected sites following experimental infection of the arm with\n            <jats:named-content content-type=\"genus-species\">H. ducreyi<\/jats:named-content>\n            . Our results suggest that\n            <jats:named-content content-type=\"genus-species\">H. ducreyi<\/jats:named-content>\n            survives in an abscess by utilizing\n            <jats:sc>l<\/jats:sc>\n            -ascorbate as an alternative carbon source, possibly taking advantage of host ascorbic acid recycling, and that\n            <jats:named-content content-type=\"genus-species\">H. ducreyi<\/jats:named-content>\n            also adapts by upregulating genes involved in anaerobic metabolism and inorganic ion and nutrient transport. 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