{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:52:56Z","timestamp":1773373976509,"version":"3.50.1"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI035681"],"award-info":[{"award-number":["AI035681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI093553"],"award-info":[{"award-number":["AI093553"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["MD011547"],"award-info":[{"award-number":["MD011547"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-1255259"],"award-info":[{"award-number":["DGE-1255259"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008028","name":"UW | School of Medicine and Public Health, University of Wisconsin-Madison","doi-asserted-by":"publisher","award":["AAA4371"],"award-info":[{"award-number":["AAA4371"]}],"id":[{"id":"10.13039\/100008028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,6,25]]},"abstract":"<jats:p>\n            Blastomycosis is a potentially life-threatening infection caused by the fungus\n            <jats:named-content content-type=\"genus-species\">Blastomyces dermatitidis<\/jats:named-content>\n            . As with related fungal diseases, blastomycosis is noted to affect some populations more than others. These patterns of illness are often not related to predisposing conditions or exposure risks; thus, genetic differences are thought to underlie these health disparities. People of Hmong ancestry in Wisconsin are at elevated risk of blastomycosis compared to the general population. We studied the genetic codes of Hmong blastomycosis patients and identified candidate sites in their genomes that may explain their susceptibility to this infection. We further studied one particular region of the genome that is involved with the immune processes that fight\n            <jats:named-content content-type=\"genus-species\">B. dermatitidis<\/jats:named-content>\n            . Our work revealed population differences in the response to fungi. A better understanding of the genetic underpinnings of susceptibility to infectious diseases has broader implications for community health, especially in the paradigm of personalized medicine.\n          <\/jats:p>","DOI":"10.1128\/mbio.01224-19","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T11:01:43Z","timestamp":1560769303000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus"],"prefix":"10.1128","volume":"10","author":[{"suffix":"Jr.","given":"Richard M.","family":"Merkhofer","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary B.","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donny","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nydiaris","family":"Hernandez-Santos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Dobson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Scott","family":"Fites","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail C.","family":"Shockey","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Wuethrich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin S.","family":"Pepperell","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Department of Medicine, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce S.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Department of Medicine, School of Medicine and Public Health, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit366"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/319203"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq215"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.07.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.21408"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-8-21"},{"key":"e_1_3_2_8_2","volume-title":"Hmong: history of a people, 3rd ed","author":"Quincy K","year":"2017","unstructured":"Quincy K. 2017. 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