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There are no effective treatment options and no vaccine for cryptosporidiosis. Therefore, there is an urgent need to identify essential gene targets and uncover their biological function to accelerate the development of new and effective anticryptosporidial drugs. Current genetic tool allows targeted disruption of gene function but leads to parasite lethality if the gene is essential for survival. In this study, we have developed a genetic tool for conditional degradation of proteins in\n                    <jats:italic>Cryptosporidium<\/jats:italic>\n                    spp., thus allowing us to study the function of essential genes. Our conditional system expands the molecular toolbox for\n                    <jats:italic>Cryptosporidium<\/jats:italic>\n                    , and it will help us to understand the biology of this important human diarrheal pathogen for the development of new drugs and vaccines.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01231-20","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T09:12:46Z","timestamp":1598260366000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["A Conditional Protein Degradation System To Study Essential Gene Function in Cryptosporidium parvum"],"prefix":"10.1128","volume":"11","author":[{"given":"Hadi H.","family":"Choudhary","sequence":"first","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, 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