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Here we generate recombinant MCMVs expressing vCXCL-1 to study vCXCL-1 function\n            <jats:italic>in vivo<\/jats:italic>\n            using MCMV as a surrogate. We demonstrate that vCXCL-1 increases MCMV dissemination kinetics for both primary and secondary dissemination. Additionally, we provide evidence, that the murine neutrophil is largely a bystander in the mouse\u2019s response to vCXCL-1. We confirm the hypothesis that vCXCL-1 is a HCMV virulence factor. Infection of severely immunocompromised mice with MCMVs expressing vCXCL-1 was lethal in more than 50% of infected animals, while all animals infected with parental virus survived during a 12-day period. This work provides needed insights into vCXCL-1 function\n            <jats:italic>in vivo<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/mbio.01289-19","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T13:54:27Z","timestamp":1561384467000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["The Human Cytomegalovirus Chemokine vCXCL-1 Modulates Normal Dissemination Kinetics of Murine Cytomegalovirus\n            <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"10","author":[{"given":"Joseph W.","family":"Jackson","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor J.","family":"Hancock","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"LaPrade","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-9855","authenticated-orcid":false,"given":"Pranay","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA"},{"name":"Columbia Center for Translational Immunology, Columbia University, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Gann","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Masi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA"},{"name":"University of Tennessee Graduate School of Medicine, Department of Surgery, University of Tennessee Medical Center, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravichandran","family":"Panchanathan","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6900-4884","authenticated-orcid":false,"given":"William E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6283-8077","authenticated-orcid":false,"given":"Steven W.","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5543-6691","authenticated-orcid":false,"given":"Tim E.","family":"Sparer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu346"},{"key":"e_1_3_2_3_2","volume-title":"Human herpesviruses: biology, therapy, and immunoprophylaxis","author":"Britt W","year":"2007","unstructured":"Britt W. 2007. 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