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No effective treatments exist for chronic toxoplasmosis due in part to a poor understanding of the biology underlying chronic infection and a lack of well-validated potential targets. We show here that a\n                    <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n                    transporter is functionally linked to protein digestion within the parasite lysosome-like organelle and that this transporter is necessary to sustain chronic infection in culture and in experimentally infected mice. Ablating the transporter results in severe bloating of the lysosome-like organelle. Together with earlier work, this study suggests the parasite\u2019s lysosome-like organelle is vital for parasite survival, thus rendering it a potential target for diminishing infection and reducing the risk of reactivated disease.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01324-19","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T08:29:01Z","timestamp":1564993741000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Role of\n                    <i>Toxoplasma gondii<\/i>\n                    Chloroquine Resistance Transporter in Bradyzoite Viability and Digestive Vacuole Maintenance"],"prefix":"10.1128","volume":"10","author":[{"given":"Geetha","family":"Kannan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, 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