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One class of host molecules toxic to\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    consists of polyunsaturated fatty acids. Here, we investigated the antibacterial properties of arachidonic acid, one of the most abundant polyunsaturated fatty acids in humans, and discovered that the mechanism of toxicity against\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    proceeds through lipid peroxidation. A better understanding of the molecular mechanisms by which the immune system kills\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    , and by which\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    avoids host killing, will enable the optimal design of therapeutics that complement the ability of the vertebrate immune response to eliminate\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    infections.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01333-19","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T10:15:23Z","timestamp":1569838523000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":94,"title":["Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism"],"prefix":"10.1128","volume":"10","author":[{"given":"William N.","family":"Beavers","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Monteith","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkataraman","family":"Amarnath","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond L.","family":"Mernaugh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"L. Jackson","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA"},{"name":"Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J.","family":"Chazin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA"},{"name":"Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA"},{"name":"Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA"},{"name":"Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-8062","authenticated-orcid":false,"given":"Sean 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