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However, knowledge of the molecular mechanisms involved in the pathogenesis of\n            <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n            remains elusive. We identified AnvM as a novel regulator of virulence in\n            <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n            . Deletion of\n            <jats:italic>anvM<\/jats:italic>\n            altered the expression levels of more than 700 genes under aerobic and anaerobic conditions, including quorum sensing system genes and oxidative stress resistance genes. AnvM directly interacted with MvfR and Anr, thus regulating their downstream genes. More importantly, AnvM directly bound to TLR2 and TLR5, which turn on the host immune response. These findings provide insights into the significance of AnvM homologs in pathogenic bacteria and suggest a potential drug target against bacterial infection.\n          <\/jats:p>","DOI":"10.1128\/mbio.01362-19","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T13:08:45Z","timestamp":1563800925000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Pseudomonas aeruginosa Regulatory Protein AnvM Controls Pathogenicity in Anaerobic Environments and Impacts Host Defense"],"prefix":"10.1128","volume":"10","author":[{"given":"Yingchao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, 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