{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:35:15Z","timestamp":1793158515689,"version":"4.5.0"},"reference-count":96,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00301850"],"award-info":[{"award-number":["RS-2023-00301850"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1I1A2A01064237"],"award-info":[{"award-number":["2019R1I1A2A01064237"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021M3A9I4021431"],"award-info":[{"award-number":["2021M3A9I4021431"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2024ER210600"],"award-info":[{"award-number":["2024ER210600"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2025,7,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The human gut contains a diverse range of microorganisms, including bacteria, viruses, protozoa, and fungi. Although research has predominantly focused on bacterial populations, emerging evidence highlights the significant role of the gut mycobiota, particularly in the context of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn\u2019s disease. This study investigates the intestinal mucosal mycobiota of UC patients, aiming to isolate and characterize live\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      fungal strains from the gut mucosa. Our analysis confirmed the presence of\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      in the intestinal mucosal layer of UC patients, with live\n                      <jats:italic toggle=\"yes\">Malassezia globosa<\/jats:italic>\n                      strains being successfully isolated. As\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      is generally associated with the skin, the genomic and transcriptomic profiles and virulence of the\n                      <jats:italic toggle=\"yes\">M. globosa<\/jats:italic>\n                      gut isolates were compared with those of the skin isolates. While both gut and skin isolates of\n                      <jats:italic toggle=\"yes\">M. globosa<\/jats:italic>\n                      shared high genomic similarity, transcriptomic analysis revealed distinct responses to oxygen levels, suggesting niche-specific adaptation. Compared with the skin isolates, the gut isolates exhibited higher virulence in a dextran sulfate sodium-induced mouse colitis model, resulting in more severe disease, reduced survival rates, and elevated proinflammatory cytokine levels in the host. Our findings highlight the potential role of\n                      <jats:italic toggle=\"yes\">M. globosa<\/jats:italic>\n                      in the pathogenesis of IBD and underscore the importance of niche-specific adaptations in fungal virulence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      fungi predominantly reside on human skin and are associated with several skin diseases, such as seborrheic dermatitis. They have also been implicated in various other diseases, including inflammatory bowel disease (IBD). While\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      DNA has been detected in many fungal microbiome studies using fecal samples, no previous research had isolated live\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      strains from the gut or confirmed that live\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      cells reside within the gut environment. In this study, we successfully isolated live\n                      <jats:italic toggle=\"yes\">Malassezia globosa<\/jats:italic>\n                      strains from the gut mucosal surface of ulcerative colitis patients and compared them to\n                      <jats:italic toggle=\"yes\">M. globosa<\/jats:italic>\n                      skin isolates. Our results revealed significant differences in pathogenicity between the gut and skin isolates and suggest the important role of\n                      <jats:italic toggle=\"yes\">M. globosa<\/jats:italic>\n                      in the gut and its involvement in IBD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.01400-25","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T09:00:33Z","timestamp":1749805233000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Live\n                    <i>Malassezia<\/i>\n                    strains from the mucosa of patients with ulcerative colitis: pathogenic potential and environmental adaptations"],"prefix":"10.1128","volume":"16","author":[{"given":"Yong-Joon","family":"Cho","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mh5ph17","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Bioscience, Kangwon National University","place":["Chuncheon-si, South Korea"]},{"id":[{"id":"https:\/\/ror.org\/01mh5ph17","id-type":"ROR","asserted-by":"publisher"}],"name":"Multidimensional Genomics Research Center, Kangwon National University","place":["Chuncheon-si, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-2444","authenticated-orcid":false,"given":"Seung Yong","family":"Shin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine, Chung-Ang University College of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Systems Biotechnology, Chung-Ang University","place":["Anseong, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Keun","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046865y68","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Life Science, Hanyang University","place":["Ansan, South Korea"]},{"name":"Center for Bionano Intelligence Education and Research","place":["Ansan, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyapat","family":"Rintarhat","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Systems Biotechnology, Chung-Ang University","place":["Anseong, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Park","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Systems Biotechnology, Chung-Ang University","place":["Anseong, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhyeon","family":"Sung","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046865y68","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Life Science, Hanyang University","place":["Ansan, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Lagree","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02pammg90","id-type":"ROR","asserted-by":"publisher"}],"name":"F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center","place":["Los Angeles, USA"]},{"id":[{"id":"https:\/\/ror.org\/02pammg90","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Underhill","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02pammg90","id-type":"ROR","asserted-by":"publisher"}],"name":"F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center","place":["Los Angeles, USA"]},{"id":[{"id":"https:\/\/ror.org\/02pammg90","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center","place":["Los Angeles, USA"]},{"id":[{"id":"https:\/\/ror.org\/05t99sp05","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2272-8321","authenticated-orcid":true,"given":"Dong-Woo","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01wjejq96","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biotechnology, Yonsei University","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohyeong","family":"Choi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Systems Biotechnology, Chung-Ang University","place":["Anseong, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7089-532X","authenticated-orcid":false,"given":"Chang Hwan","family":"Choi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine, Chung-Ang University College of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-961X","authenticated-orcid":false,"given":"Chul-Su","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046865y68","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Life Science, Hanyang University","place":["Ansan, South Korea"]},{"name":"Center for Bionano Intelligence Education and Research","place":["Ansan, South Korea"]},{"id":[{"id":"https:\/\/ror.org\/046865y68","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicinal and Life Science, Hanyang University","place":["Ansan, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6920-0233","authenticated-orcid":true,"given":"Won Hee","family":"Jung","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r024a98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Systems Biotechnology, Chung-Ang University","place":["Anseong, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10208"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.09.013"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0415-0"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.06.030"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2023-325668"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2022.138"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.4110\/in.2017.17.1.25"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2041342"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i1.5"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000525925"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2023.102319"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI155786"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1221789"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.03.006"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-040820-010114"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","unstructured":"Brayer KJ Hanson JA Cingam S Martinez C Ness SA Rabinowitz I. 2023. The immune response to a fungus in pancreatic cancer samples. bioRxiv:2023.03.28.534606. doi:10.1101\/2023.03.28.534606","DOI":"10.1101\/2023.03.28.534606"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170058"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00159"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13786"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326298"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv209"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9020139"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2012.03563.x"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02267-22"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.007"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00419"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399623"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2015.251"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000560"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaa226"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2019.02.031"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008478"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.041"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01432-7"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066019"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12586"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00506-22"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005614"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003473117"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV120.011188"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105202"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-021-01623-1"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.09.006"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518260113"},{"key":"e_1_3_5_46_2","first-page":"238","article-title":"Clinicopathologic study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper HS","year":"1993","unstructured":"Cooper HS, Murthy SN, Shah RS, Sedergran DJ. 1993. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69:238\u2013249.","journal-title":"Lab Invest"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190613"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/10_2013_203"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50823-9"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i41.5848"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.017"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00816-w"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0373-4"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310746"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-023-01072-w"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myab076"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1530-7"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003847"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003315"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.174623.114"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001822"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010012"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.3.310"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/g3journal\/jkad159"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6mt00301j"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myac083"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1097(99)00536-4"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1706.091866"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.8.4586"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.11.006"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.05.004"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01997"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2020.100036"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09436-x"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00387-08"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008137"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.05.001"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv008"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_3_5_81_2","unstructured":"Dore J Ehrlich SD Levenez F Pelletier E Alberti A Bertrand L Bork P Costea PI Sunagawa S Guarner F Manichanh C Santiago A Zhao L Shen J Zhang C Versalovic J Luna RA Petrosino J Yang H Li S Wang J Allen\u2010Vercoe E Gloor G Singh B. 2015. IHMS_SOP 06 V1: standard operating procedure for fecal samples DNA extraction Protocol Q. International Human Microbiome Standards"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.231129"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt593"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.04.004"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx353"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3176"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1137\/040608635"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv681"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt214"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac194"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00199"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121954"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01615.x"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01400-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01400-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T13:05:17Z","timestamp":1752066317000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01400-25"}},"subtitle":[],"editor":[{"given":"Alexander","family":"Idnurm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":96,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,9]]}},"alternative-id":["10.1128\/mbio.01400-25"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01400-25","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"2025-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01400-25"}}