{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:27:36Z","timestamp":1787063256535,"version":"build-2736575974"},"reference-count":70,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Milstein Program in Chemical Biology and Translational Medicine","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI11143"],"award-info":[{"award-number":["U19AI11143"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:p>\n                    Antimycobacterial agents might shorten the course of treatment by reducing the number of phenotypically tolerant bacteria if they could kill\n                    <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n                    in diverse metabolic states. Here we report two chemically disparate classes of agents that kill\n                    <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n                    both when it is replicating and when it is not. Under replicating conditions, the tricyclic 4-hydroxyquinolines and a barbituric acid analogue deplete intrabacterial magnesium as a mechanism of action, and for both compounds, mutations in CorA, a putative Mg\n                    <jats:sup>2+<\/jats:sup>\n                    \/Co\n                    <jats:sup>2+<\/jats:sup>\n                    transporter, conferred resistance to the compounds when\n                    <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n                    was under replicating conditions but not under nonreplicating conditions, illustrating that a given compound can kill\n                    <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n                    in different metabolic states by disparate mechanisms. Targeting magnesium metallostasis represents a previously undescribed antimycobacterial mode of action that might cripple\n                    <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n                    in a Mg\n                    <jats:sup>2+<\/jats:sup>\n                    -deficient intraphagosomal environment of macrophages.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01405-19","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T05:23:19Z","timestamp":1562563399000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA"],"prefix":"10.1128","volume":"10","author":[{"given":"Landys","family":"Lopez Quezada","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Silve","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kelinske","sequence":"additional","affiliation":[{"name":"Agilent Technologies, Inc., Wilmington, Delaware, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Liba","sequence":"additional","affiliation":[{"name":"Agilent Technologies, Inc., Wilmington, Delaware, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantino","family":"Diaz Gonzalez","sequence":"additional","affiliation":[{"name":"Evotec Research Informatics (Toulouse), Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kotev","sequence":"additional","affiliation":[{"name":"Evotec Research Informatics (Toulouse), Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Goullieux","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Sans","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Roubert","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bacqu\u00e9","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Couturier","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Pellet","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Blanc","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Ferron","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Debu","sequence":"additional","affiliation":[{"name":"Evotec Infectious Diseases (Lyon), Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelin","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-5767","authenticated-orcid":false,"given":"Jeffrey","family":"Aub\u00e9","sequence":"additional","affiliation":[{"name":"Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-8896","authenticated-orcid":false,"given":"Carl","family":"Nathan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization. 2015. Global tuberculosis report. World Health Organization Geneva Switzerland. https:\/\/www.who.int\/tb\/publications\/global_report\/en\/."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09657"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003081"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78538-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.2062-2069.1996"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.033084-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00803-15"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ml200157f"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9010719"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq145"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21531"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309171110"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm500131s"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00112"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.1196-1203.2005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2450-9_18"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.02.003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S49763"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20033582"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4690"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02133-16"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121745"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76514-3"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7174-z"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001507200"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M901581200"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004645"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0762-9"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90086-C"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016058229972"},{"key":"e_1_3_2_33_2","first-page":"1317","article-title":"Far infrared study of metal-pyridine complexes","volume":"29","author":"Clark RJH","year":"1964","unstructured":"Clark RJH, Williams CS. 1964. Far infrared study of metal-pyridine complexes. Chem Ind-London 29:1317\u20131318.","journal-title":"Chem Ind-London"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006819"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152449"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612810114"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05114-14"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00716a029"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.162.1.413-419.1985"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95867-9"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-12-1096"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb02197.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.3.1491"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01797.x"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-003-2496-4"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(62)86841-6"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.11.016"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.05.008"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.042"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-051313-051025"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.2741\/2039"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4590"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.288"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.171.9.4761-4766.1989"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62288-4"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00048-2"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.15"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.08.006"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12454"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07273.x"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209018109"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.055"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.08.009"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01833"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00025"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.26.2.167-200.1933"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.3791\/54690"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00325-16"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp400592n"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-130-8-1883"}],"container-title":["mBio"],"original-title":[],"contributor":[{"given":"Michael","family":"Niederweis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Ferric","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Marcela","family":"Rodriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01405-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01405-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T21:26:26Z","timestamp":1646688386000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01405-19"}},"subtitle":[],"editor":[{"given":"Eric J.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8,27]]}},"alternative-id":["10.1128\/mBio.01405-19"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01405-19","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,27]]},"assertion":[{"value":"2019-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01405-19"}}