{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:31:58Z","timestamp":1793338318885,"version":"4.5.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1087415"],"award-info":[{"award-number":["APP1087415"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1071822"],"award-info":[{"award-number":["APP1071822"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1059012"],"award-info":[{"award-number":["APP1059012"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1137127"],"award-info":[{"award-number":["APP1137127"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2018,11,7]]},"abstract":"<jats:p>\n            Actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC) are two of the most common dermatologic conditions in Western countries and cause substantial morbidity worldwide. The role of human papillomaviruses under these conditions has been well studied yet remains inconclusive. One PCR-based study has investigated bacteria in the etiology of these conditions; however, no study has investigated the microbiomes of AK and SCC more broadly. We longitudinally profiled the microbiomes of 112 AK lesions, profiled cross sections of 32 spontaneously arising SCC lesions, and compared these to matching nonlesional photodamaged control skin sites. We identified commonly occurring strains of\n            <jats:italic>Propionibacterium<\/jats:italic>\n            and\n            <jats:italic>Malassezia<\/jats:italic>\n            at higher relative abundances on nonlesional skin than in AK and SCC lesions, and strains of\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            were relatively more abundant in lesional than nonlesional skin. These findings may aid in the prevention of SCC.\n          <\/jats:p>","DOI":"10.1128\/mbio.01432-18","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T13:23:12Z","timestamp":1539004992000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes"],"prefix":"10.1128","volume":"9","author":[{"given":"David L. A.","family":"Wood","sequence":"first","affiliation":[{"name":"Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Lachner","sequence":"additional","affiliation":[{"name":"Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Tan","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Dermatology Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia"},{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Tang","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Dermatology Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia"},{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Angel","sequence":"additional","affiliation":[{"name":"Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Laino","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Dermatology Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia"},{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Linedale","sequence":"additional","affiliation":[{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-Anh","family":"L\u00ea Cao","sequence":"additional","affiliation":[{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"School of Mathematics and Statistics, Melbourne Integrative Genomics, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Morrison","sequence":"additional","affiliation":[{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Frazer","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Dermatology Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia"},{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Peter","family":"Soyer","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Dermatology Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia"},{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hugenholtz","sequence":"additional","affiliation":[{"name":"Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02560.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700776"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5070\/D3204022368"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.4671.2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12420"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0551"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-012-0367-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02558.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.03.020"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0905"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2537"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.3.505"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440102"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2009.153"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607077104"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/STA-200066418"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160169"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2016.03.002"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12171"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-139-8-1745"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706756104"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002719"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/annotation\/bcff4a59-10b7-442a-8181-12fa69209e57"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00021-11"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.106"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021581"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-313"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2009.00565.x"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00742.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00012-10"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100994108"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00416.x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.134"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.06.001"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177486"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq461"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03006-05"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.112730.110"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp636"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_3_50_2","unstructured":"Oksanen J Blanchet FG Friendly M Kindt R Legendre P McGlinn D Minchin PR O'Hara RB Simpson GL Solymos P Stevens MHH Szoecs E Wagner H. 2018. vegan: Community Ecology Package. R package version 2.3-3. https:\/\/CRAN.R-project.org\/package=vegan."},{"key":"e_1_3_3_51_2","doi-asserted-by":"crossref","unstructured":"Aitchison J. 1982. The statistical analysis of compositional data. J Royal Statistical Society Series B (Methodological) 44:139\u2013177. www.jstor.org\/stable\/2345821.","DOI":"10.1111\/j.2517-6161.1982.tb01195.x"},{"key":"e_1_3_3_52_2","author":"Kolde R","year":"2015","unstructured":"Kolde R. 2015. Package pheatmap. R Package 1\u20137.","journal-title":"Package pheatmap"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004226"}],"container-title":["mBio"],"original-title":[],"contributor":[{"given":"Gary","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Simone","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01432-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01432-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T02:13:20Z","timestamp":1646705600000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01432-18"}},"subtitle":[],"editor":[{"given":"Claire M.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,7]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11,7]]}},"alternative-id":["10.1128\/mBio.01432-18"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01432-18","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,7]]},"assertion":[{"value":"2018-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01432-18"}}