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Astroviruses have been detected from the central nervous system of mammals in association with disease, suggesting that this family of RNA viruses could be responsible for cases of some neurological diseases that are currently without an ascribed etiology. However, there are significant barriers to understanding astrovirus infection as the capacity of these viruses to replicate in nervous system cells\n            <jats:italic>in vitro<\/jats:italic>\n            has not been determined. We describe primary and immortalized cultured cells of the nervous system that support infection by astroviruses. 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