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Among\n                    <jats:italic>Malassezia<\/jats:italic>\n                    species,\n                    <jats:italic>Malassezia restricta<\/jats:italic>\n                    is the most widely observed species on the human skin. In the current study, we identified a novel dsRNA virus, named MrV40, in\n                    <jats:italic>M. restricta<\/jats:italic>\n                    and characterized the sequence and structure of the viral genome along with an independent satellite dsRNA viral segment. Moreover, expression of genes involved in ribosomal synthesis and programmed cell death was altered, indicating that virus infection affected the physiology of the fungal host cells. Our data also showed that the viral nucleic acid from MrV40 induces a TLR3-mediated inflammatory immune response in bone marrow-derived dendritic cells, indicating that a viral element likely contributes to the pathogenicity of\n                    <jats:italic>Malassezia<\/jats:italic>\n                    . This is the first study to identify and characterize a novel mycovirus in\n                    <jats:italic>Malassezia<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/mbio.01521-20","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T09:43:07Z","timestamp":1598866987000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["A Novel Virus Alters Gene Expression and Vacuolar Morphology in\n                    <i>Malassezia<\/i>\n                    Cells and Induces a TLR3-Mediated Inflammatory Immune Response"],"prefix":"10.1128","volume":"11","author":[{"given":"Minji","family":"Park","sequence":"first","affiliation":[{"name":"Department of Systems Biotechnology, Chung-Ang University, Anseong, South 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