{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:01:56Z","timestamp":1790805716069,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI109799"],"award-info":[{"award-number":["AI109799"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HHS-NIH-NIAID","award":["AI129992"],"award-info":[{"award-number":["AI129992"]}]},{"name":"HHS-NIH-NIAID","award":["AI007025"],"award-info":[{"award-number":["AI007025"]}]},{"name":"US Department of Agriculture, National Institute for Food and Agriculture Postdoctoral Fellowship","award":["2016-67012-25179"],"award-info":[{"award-number":["2016-67012-25179"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Brucella abortus<\/jats:named-content>\n            infects the placenta of pregnant cows, where it replicates to high levels and triggers abortion of the calf. The aborted material is highly infectious and transmits infection to both cows and humans, but very little is known about how\n            <jats:named-content content-type=\"genus-species\">B. abortus<\/jats:named-content>\n            causes abortion. By studying this infection in pregnant mice, we discovered that\n            <jats:named-content content-type=\"genus-species\">B. abortus<\/jats:named-content>\n            kills trophoblasts, which are important cells for maintaining pregnancy. This killing required an injected bacterial protein (VceC) that triggered an endoplasmic reticulum (ER) stress response in the trophoblast. By inhibiting ER stress or infecting mice that lack CHOP, a protein induced by ER stress, we could prevent death of trophoblasts, reduce inflammation, and increase the viability of the pups. Our results suggest that\n            <jats:named-content content-type=\"genus-species\">B. abortus<\/jats:named-content>\n            injects VceC into placental trophoblasts to promote its transmission by abortion.\n          <\/jats:p>","DOI":"10.1128\/mbio.01538-19","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T13:08:45Z","timestamp":1563800925000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-4156","authenticated-orcid":false,"given":"Mariana X.","family":"Byndloss","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, 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