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The mechanism underlying this protection has remained elusive. Here, we reveal the comprehensive strategy by which the cervicovaginal microbiota modulates host functions to protect against chlamydial infection, thereby providing a novel conceptual mechanistic understanding. Major implications of this work are that (i) the impact of the vaginal microbiota on the epithelium should be considered in future studies of chlamydial infection and other STIs and (ii) a fundamental understanding of the cervicovaginal microbiota\u2019s role in protection against STIs may enable the development of novel microbiome-based therapeutic strategies to protect women from infection and improve vaginal and cervical health.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01548-19","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T08:29:01Z","timestamp":1564993741000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":164,"title":["The Cervicovaginal Microbiota-Host Interaction Modulates Chlamydia trachomatis Infection"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-4468","authenticated-orcid":false,"given":"Vonetta 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