{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:01:41Z","timestamp":1789732901325,"version":"4.0.1"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2014,8,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The global spread of antibiotic-resistant bacteria has largely been driven by the dissemination of successful lineages. A particularly important example is sequence type (ST) 258 of\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            , a common cause of health care-associated infections. Representatives of this lineage carry a variable array of plasmid-borne resistance genes, typically including a carbapenemase effective against the full range of clinically important \u03b2-lactams. In their recent\n            <jats:italic>mBio<\/jats:italic>\n            article, Chen et al. [\n            <jats:italic>mBio<\/jats:italic>\n            5(3):e01355-14] described how ST258 emerged through \u201chybridization\u201d between two other strains, with a second recombination resulting in the diversification of a key antigen. This commentary describes the findings in the context of other examples where saltational evolution has resulted in the sudden emergence of important pathogenic bacteria.\n          <\/jats:p>","DOI":"10.1128\/mbio.01550-14","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T04:04:50Z","timestamp":1406693090000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["The Emergence of Bacterial \u201cHopeful Monsters\u201d"],"prefix":"10.1128","volume":"5","author":[{"given":"Nicholas J.","family":"Croucher","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Imperial College London, St. Mary\u2019s Campus, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith P.","family":"Klugman","sequence":"additional","affiliation":[{"name":"Bill and Melinda Gates Foundation, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","volume-title":"Antimicrobial resistance: global report on surveillance","author":"World Health Organization","year":"2014","unstructured":"World Health Organization . 2014. Antimicrobial resistance: global report on surveillance. 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