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The dearth of new antibiotics to treat gonorrhea demands that alternative curative strategies be considered to counteract antibiotic resistance expressed by gonococci. Herein, we show that decreased expression of a drug efflux pump that participates in gonococcal resistance to antibiotics can increase gonococcal susceptibility to beta-lactams and macrolides under laboratory conditions, as well as improve antibiotic-mediated clearance of gonococci from the genital tract of experimentally infected female mice.<\/jats:p>","DOI":"10.1128\/mbio.01576-19","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T12:26:53Z","timestamp":1565612813000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Could Dampening Expression of the Neisseria gonorrhoeae\n            <i>mtrCDE<\/i>\n            -Encoded Efflux Pump Be a Strategy To Preserve Currently or Resurrect Formerly Used Antibiotics To Treat Gonorrhea?"],"prefix":"10.1128","volume":"10","author":[{"given":"Shaochun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology and the Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA"},{"name":"Laboratories of Bacterial Pathogenesis, VA Medical Center, Decatur, Georgia, USA"},{"name":"National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing, China"},{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristie L.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, F. 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