{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:10:14Z","timestamp":1792174214176,"version":"4.4.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The National Key Research and Development Program of China","award":["2017YFD0500400"],"award-info":[{"award-number":["2017YFD0500400"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31672544"],"award-info":[{"award-number":["31672544"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Municipal Natural Science Foundation","award":["6172023"],"award-info":[{"award-number":["6172023"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2018,11,7]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Toxoplasma gondii<\/jats:named-content>\n            is one of the most successful human parasites, infecting nearly one-third of the total world population.\n            <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n            tachyzoites residing within parasitophorous vacuoles (PVs) can acquire fatty acids both via salvage from host cells and via\n            <jats:italic>de novo<\/jats:italic>\n            synthesis pathways for membrane biogenesis. However, although fatty acid fluxes are known to exist in this parasite, how fatty acids flow through\n            <jats:italic>Toxoplasma<\/jats:italic>\n            lipid metabolic organelles, especially mitochondria, remains unknown. In this study, we demonstrated that\n            <jats:italic>Toxoplasma<\/jats:italic>\n            expresses an active ankyrin repeat containing protein TgACBP2 to coordinate cardiolipin metabolism. Specifically, HMA acquisition resulting from heterologous functional expression of MAF1 rescued growth and lipid metabolism defects in ACBP2-deficient type II parasites, manifesting the complementary role of host mitochondria in parasite cardiolipin metabolism. This work highlights the importance of TgACBP2 in parasite cardiolipin metabolism and provides evidence for metabolic association of host mitochondria with\n            <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/mbio.01597-18","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T10:18:27Z","timestamp":1540203507000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Comprehensive Characterization of\n            <i>Toxoplasma<\/i>\n            Acyl Coenzyme A-Binding Protein TgACBP2 and Its Critical Role in Parasite Cardiolipin Metabolism"],"prefix":"10.1128","volume":"9","author":[{"given":"Yong","family":"Fu","sequence":"first","affiliation":[{"name":"National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China"},{"name":"Key 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