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To achieve a better understanding of the bacterial factors facilitating the development of these metastatic infections, we used in this study a\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n                    transposon mutant library in a murine model of intravenous infection, where bacteria first colonize the liver as the primary infection site and subsequently progress to secondary sites such as the kidney and bones. We identified a novel LysR-type transcriptional regulator (LTTR), which was specifically required by\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    for efficient colonization of secondary organs. We also determined the transcriptional activation as well as the regulon of LTTR, which suggests that this regulator is involved in the metabolic adaptation of\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    to the host microenvironment found in secondary infection sites.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01646-20","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T09:12:46Z","timestamp":1598260366000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Identification of a Novel LysR-Type Transcriptional Regulator in Staphylococcus aureus That Is Crucial for Secondary Tissue Colonization during Metastatic Bloodstream Infection"],"prefix":"10.1128","volume":"11","author":[{"given":"Michaela","family":"Groma","sequence":"first","affiliation":[{"name":"Chair of Microbiology, 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