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During intestinal colonization,\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      relies on the coordinated action of the SPI-4 encoded type I secretion system (T1SS) and SPI-1 encoded type III secretion system (T3SS-1) to breach epithelial barriers. Although the T3SS-1 and its effectors have been widely studied, the T1SS and its associated effectors remain poorly characterized. The T1SS-secreted substrate SiiE binds to host cell surface mucins via its bacterial Ig-like (BIg) domain, facilitating the proper positioning of the T3SS-1 and subsequently triggering bacterial internalization. Given the critical role of the T1SS and SiiE in\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      virulence, they may serve as promising targets for anti-virulence drug development. In this review, we provide an overview of the current knowledge on the T1SS, including its regulatory mechanisms, channel formation, and the functional properties of SiiE.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.01655-25","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:01:19Z","timestamp":1758546079000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Emerging insights into the type I secretion system: a key player in\n                    <i>Salmonella<\/i>\n                    virulence and host-pathogen interactions"],"prefix":"10.1128","volume":"16","author":[{"given":"Siqi","family":"Li","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04r17kf39","id-type":"ROR","asserted-by":"publisher"}],"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key 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