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Influenza virus NA is a key target antigen as a component of a next-generation vaccine in the influenza field, with evidence for a role in protective immunity in humans. However, mechanisms of protection provided by antibodies directed to NA remain largely unexplored. Herein, we show that antibody Fc interaction with Fc\u03b3 receptors (Fc\u03b3Rs) expressed on effector cells contributes to viral control in a murine model of influenza. Importantly, a chimeric mouse-human IgG1 with no direct antiviral activity was demonstrated to solely rely on Fc\u03b3Rs to protect mice from disease. Therefore, antibodies without NA enzymatic inhibitory activity may also play a role in controlling influenza viruses and should be of consideration when designing NA-based vaccines and assessing immunogenicity.<\/jats:p>","DOI":"10.1128\/mbio.01667-19","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T08:34:44Z","timestamp":1571646884000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Fc\u03b3 Receptors Contribute to the Antiviral Properties of Influenza Virus Neuraminidase-Specific Antibodies"],"prefix":"10.1128","volume":"10","author":[{"given":"E. 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