{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:17Z","timestamp":1792787237080,"version":"4.5.0"},"reference-count":73,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/AuthorWarrantyLicense.v1"},{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"CDC Office of Antimicrobial Resistance"},{"name":"Combating Antibiotic Resistance Bacteria (CARB) initiative"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,10,29]]},"abstract":"<jats:p>\n                    Gonorrhea, a sexually transmitted disease, causes substantial global morbidity and economic burden. New prevention and control measures for this disease are urgently needed, as strains resistant to almost all classes of antibiotics available for treatment have emerged. Previous reports demonstrate that cross-protection from gonococcal infections may be conferred by meningococcal serogroup B (MenB) outer membrane vesicle (OMV)-based vaccines. Among 1,525 common proteins shared across the genomes of both\n                    <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n                    , 57 proteins were predicted to be surface expressed (outer membrane proteins [OMPs]) and thus preferred targets for vaccine development. The majority of these OMPs showed high sequence identity between the 2 bacterial species. Our results provide valuable insight into the meningococcal antigens present in the current OMV-containing MenB-4C vaccine that may contribute to cross-protection against gonorrhea and may inform next steps in gonorrhea vaccine development.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01668-19","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T08:35:27Z","timestamp":1568018127000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Genetic Similarity of Gonococcal Homologs to Meningococcal Outer Membrane Proteins of Serogroup B Vaccine"],"prefix":"10.1128","volume":"10","author":[{"given":"Henju","family":"Marjuki","sequence":"first","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Topaz","sequence":"additional","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep J.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, IHRC, Inc., Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M.","family":"Gernert","sequence":"additional","affiliation":[{"name":"Laboratory Reference and Research Branch, Division of STD Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen N.","family":"Kersh","sequence":"additional","affiliation":[{"name":"Laboratory Reference and Research Branch, Division of STD Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Antimicrobial-Resistant Neisseria gonorrhoeae Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.12.7063-7072.2002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2012.02903.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.11109"},{"key":"e_1_3_2_5_2","unstructured":"Todar K. 2008. Pathogenic neisseriae: gonorrhea neonatal ophthalmia and meningococcal meningitis. Todar\u2019s online textbook of bacteriology. http:\/\/textbookofbacteriology.net\/neisseria.html."},{"key":"e_1_3_2_6_2","first-page":"1","article-title":"Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"62","author":"Cohn AC","year":"2013","unstructured":"Cohn AC, MacNeil JR, Clark TA, Ortega-Sanchez IR, Briere EZ, Meissner HC, Baker CJ, Messonnier NE, Centers for Disease Control and Prevention (CDC). 2013. Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 62:1\u201328.","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics7030059"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2015.1105782"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00010-14"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283389141"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.02.081"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090816-093530"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/2051013616681365"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.34293"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(83)90340-9"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.05.001"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2017.1329276"},{"key":"e_1_3_2_20_2","first-page":"53","article-title":"Mucosal approaches in Neisseria vaccinology","volume":"18","author":"Perez O","year":"2009","unstructured":"Perez O, del Campo J, Cuello M, Gonzalez E. 2009. Mucosal approaches in Neisseria vaccinology. VacciMonitor 18:53\u201355.","journal-title":"VacciMonitor"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31449-6"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2206.151093"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1061"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.36221"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.24129"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.01101.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2005.apm_206.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201400395"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.4.486-491.2006"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.10.074"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500164"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.5.5.7367"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.01.011"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.02.023"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500821"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01424-06"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2.8.895"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5459.1816"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00554-5"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.01.033"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.70"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.08.067"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.09.114"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep19953"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00186-17"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182555"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.12.132"},{"key":"e_1_3_2_48_2","first-page":"29","article-title":"Gonococcal vaccine studies in Inuvik","volume":"65","author":"Greenberg L","year":"1974","unstructured":"Greenberg L, Diena BB, Ashton FA, Wallace R, Kenny CP, Znamirowski R, Ferrari H, Atkinson J. 1974. Gonococcal vaccine studies in Inuvik. Can J Public Health 65:29\u201333.","journal-title":"Can J Public Health"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(91)90147-X"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003528"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603940103"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.539510"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-263954"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2015.0023"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.4.5.667"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00625-13"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr301208g"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy609"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.058800"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.029538"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00898-16"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154047"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003559"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.11"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-595"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099368"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky320"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg602"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.9.847"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1701"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.75"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw290"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01668-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01668-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:07:54Z","timestamp":1646690874000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01668-19"}},"subtitle":[],"editor":[{"given":"Rino","family":"Rappuoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":73,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10,29]]}},"alternative-id":["10.1128\/mBio.01668-19"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01668-19","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"assertion":[{"value":"2019-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01668-19"}}