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It is striking that aspergilli have developed and maintained a multinucleate nurse cell that is presumably energy-intensive to produce and is usually found only in higher eukaryotes. Our findings shed light on how the understudied H\u00fclle cells might contribute to the success of aspergilli by acting not only as nurse cells under detrimental conditions (sexual development) but also as fungal backup stem cells with the capacity to produce genetically diverse spores in an accelerated manner, thereby substantially contributing to survival in response to predator attack or under otherwise severely destructive conditions. Our study solved the 90-year-old puzzle of H\u00fclle cell germination and provides easy, reproducible methods that will facilitate future studies on biological and ecological roles of H\u00fclle cells in aspergilli.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01673-20","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:24:42Z","timestamp":1597051482000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["H\u00fclle Cells of Aspergillus nidulans with Nuclear Storage and Developmental Backup Functions Are Reminiscent of Multipotent Stem Cells"],"prefix":"10.1128","volume":"11","author":[{"given":"Danielle M.","family":"Troppens","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Genetics, Georg-August-University, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Genetics, Georg-August-University, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabea","family":"Schl\u00fcter","sequence":"additional","affiliation":[{"name":"Imaging Center of the Department of Biology, University of Greifswald, Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hoppert","sequence":"additional","affiliation":[{"name":"Department of General Microbiology, Georg-August-University, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Gerke","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Genetics, Georg-August-University, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-5626","authenticated-orcid":false,"given":"Gerhard H.","family":"Braus","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Genetics, Georg-August-University, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"21st century guidebook to fungi","author":"Moore D","year":"2011","unstructured":"Moore D, Robson GD, Trinci AP. 2011. 21st century guidebook to fungi. 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