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Here, we identified an alkaline phosphatase (ALPP) that is expressed primarily in placental tissue and promotes ZIKV infection by colocalizing with ZIKV proteins and preventing their proteasome-mediated degradation. The phosphatase activity of ALPP could be required for optimal ZIKV infection, and ALPP is stabilized by BIP via its chaperone activity. This report provides novel insights into host factors required for ZIKV infection, which potentially has implications for ZIKV infection of the placenta.<\/jats:p>","DOI":"10.1128\/mbio.01716-20","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T14:36:30Z","timestamp":1600094190000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1090-5586","authenticated-orcid":false,"given":"Jian","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Public Health Clinical Center &amp; Shanghai Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilu","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center &amp; 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