{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:32:58Z","timestamp":1791495178856,"version":"4.3.4"},"reference-count":103,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The commensal and pathogenic lifestyles of the opportunistic fungal pathogen\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      require complex signaling networks regulated by protein kinases. To investigate the role of\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      protein kinases at the intestinal epithelial interface, we screened a comprehensive protein kinase deletion library for the capacity of the mutants to damage intestinal epithelial cells (IEC). Mutants showing altered IEC cytotoxicity relative to the wild type were further analyzed for their growth and morphology, focusing on hyper-damaging strains to identify kinases that rather prevent host cell damage. Deletion of\n                      <jats:italic toggle=\"yes\">CRK1<\/jats:italic>\n                      caused increased IEC-specific damage, despite slower growth, reduced hyphal length, and reduced adhesion as compared to wild-type cells. While tissue invasion levels and the formation of transcellular tunnels of the\n                      <jats:italic toggle=\"yes\">crk1<\/jats:italic>\n                      \u0394\/\u0394 mutant were increased, the translocation capacity through the IEC barrier was reduced. Transcriptional and metabolic profiling suggested a role for Crk1 in metabolic adaptation to carbon and nitrogen sources, which was validated by showing that high glucose and amino acids are required for\n                      <jats:italic toggle=\"yes\">crk1<\/jats:italic>\n                      \u0394\/\u0394 to cause increased IEC damage. Deletion of\n                      <jats:italic toggle=\"yes\">CRK1<\/jats:italic>\n                      rendered\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      more susceptible to cell wall and membrane stressors, but caused higher resistance to a catalase-specific and histidine biosynthesis inhibitor. This phenotypic pattern of medium- and epithelial cell type-specific cytotoxicity displayed by a\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      protein kinase mutant suggests that Crk1 regulates processes linked to carbon and amino acid metabolism that are relevant to interactions with intestinal epithelial cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      Microbial signal transduction pathways regulate adaptation to changing environmental conditions and facilitate the success of many microbes during interactions with their hosts. The fungal pathobiont\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      exists as a harmless commensal on mucosal surfaces of most humans but can also cause superficial and invasive infections under certain circumstances. Both lifestyles require complex signaling networks, predominantly regulated by protein kinases. The\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      genome was predicted to encode 108 protein kinases, yet nearly 50% remain uncharacterized. We aimed to dissect the role of\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      protein kinases during the transition from commensal to pathogen. We showed that multiple protein kinase genes are involved in epithelial cell damage. Particularly, the protein kinase gene Crk1 was of interest because deletion of CRK1 caused increased damage to intestinal epithelial cells under distinct conditions. Our study links Crk1 with regulation of metabolic processes relevant for commensalism and pathogenicity of\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.01764-26","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:00:47Z","timestamp":1787230847000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Functional analysis of\n                    <i>Candida albicans<\/i>\n                    protein kinases identifies Crk1 as a modulator of epithelial cell damage"],"prefix":"10.1128","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2741-2714","authenticated-orcid":false,"given":"Anna","family":"M\u00f6slinger","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allon","family":"Weiner","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02en5vm52","id-type":"ROR","asserted-by":"publisher"}],"name":"Sorbonne Universit\u00e9, CNRS, Inserm, Centre d\u2019immunologie et des maladies infectieuses, CIMI","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-6546","authenticated-orcid":true,"given":"Sascha","family":"Sch\u00e4uble","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiome Dynamics, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Ram\u00edrez-Zavala","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Molecular Infection Biology, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Jablonowski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Cseresny\u00e9s","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim B.","family":"Schille","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"publisher"}],"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Thilo","family":"Figge","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"publisher"}],"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Biological Sciences, Friedrich Schiller University","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Panagiotou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiome Dynamics, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"publisher"}],"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Biological Sciences, Friedrich Schiller University","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/035rzkx15","id-type":"ROR","asserted-by":"publisher"}],"name":"Jena University Hospital","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-8687","authenticated-orcid":true,"given":"Joachim","family":"Morschh\u00e4user","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Molecular Infection Biology, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Kasper","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]},{"name":"Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institute","place":["Greifswald, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Gresnigt","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Junior Research Group Adaptive Pathogenicity Strategies, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-4824","authenticated-orcid":false,"given":"Stefanie","family":"Allert","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"publisher"}],"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6028-0425","authenticated-orcid":true,"given":"Bernhard","family":"Hube","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans-Kn\u00f6ll-Institute","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"publisher"}],"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena","place":["Jena, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Biological Sciences, Friedrich Schiller University","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000713"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054379"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0373-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2287618"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00021-23"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-025-01174-x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaf013"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.FUNK-0014-2016"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.02.009"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/323759"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0709-7"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511399285"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsml\/uqag001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00915-18"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036952"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2154548"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.05.006"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01394.x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149159"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13378"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17625"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110187"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.09.008"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12495"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.157"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07142-4"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.5.1053-1060.2003"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006699"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.07.001"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001510"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01644-25"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010283"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01249-24"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106145"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000752"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920310794557655"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01813.x"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00295-13"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01698-24"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.23.8696-8708.2000"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.10.3058-3068.1999"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61701-5"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8010048"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01581-18"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2023.2174294"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5040107"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.039719"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.7.2058-2061.2002"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-03-0272"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00044-12"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00915-13"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.11.4049-4061.2000"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.19.5850-5852.1996"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32792-6"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-03-0181"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006131"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087128"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9080787"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/foae010"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02211-16"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31237-z"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005602"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30661-5"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01733-24"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-026-04767-5"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.09.011"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12251"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbr.2025.100427"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108781"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.1373"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.10.007"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009622"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004567"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-36191-4"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01344-17"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.01009.x"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00524.x"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.07003.x"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24095-8"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00311-25"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00172-3"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.05.003"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.12.8422"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104384"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(02)01201-6"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1146848"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444913022579"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.107.3.719"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf507"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01269.x"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13887"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330291"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.06.021"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.102.3.581"},{"key":"e_1_3_4_96_2","first-page":"621","article-title":"Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck","volume":"75","author":"Rupniak HT","year":"1985","unstructured":"Rupniak HT, Rowlatt C, Lane EB, Steele JG, Trejdosiewicz LK, Laskiewicz B, Povey S, Hill BT. 1985. Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck. J Natl Cancer Inst 75:621\u2013635.","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-290-2_7"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-04344-9"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01744-4"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3730"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","unstructured":"Seelbinder B Wolf T Priebe S McNamara S Gerber S Guthke R Linde J. 2019 GEO2RNAseq: An easy-to-use R pipeline for complete pre-processing of RNA-seq data. Bioinformatics. doi:10.1101\/771063","DOI":"10.1101\/771063"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50491-x"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01764-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01764-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:02:28Z","timestamp":1788958948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01764-26"}},"subtitle":[],"editor":[{"given":"Marcio","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":103,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,9]]}},"alternative-id":["10.1128\/mbio.01764-26"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01764-26","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"2026-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01764-26"}}