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Prior studies proposed that systemic tissues were colonized by a pool of intestinal replicating bacteria distinct from populations within Peyer\u2019s patches and mesenteric lymph nodes. Whether bacteria within intestinal pyogranulomas serve as the source for systemic dissemination and the relationship between bacterial populations within different tissue sites is poorly defined. Moreover, the host factors that regulate\n                      <jats:italic toggle=\"yes\">Yersinia<\/jats:italic>\n                      colonization and dissemination are not well understood. Here, we demonstrate using sequence tag-based analysis of microbial populations in R (STAMPR) that remarkably small founder populations independently colonize intestinal and systemic tissues. Notably, intestinal pyogranulomas contain clonal populations of bacteria that are restricted and do not spread to other tissues. However,\n                      <jats:italic toggle=\"yes\">Yersinia<\/jats:italic>\n                      populations are shared among systemic organs and the blood, suggesting that systemic dissemination occurs via hematogenous spread. Finally, we demonstrate that TNF signaling is a key contributor to the bottlenecks limiting both initial colonization and subsequent dissemination of orally acquired bacterial populations. Altogether, this study reveals previously undescribed aspects of infection dynamics of enteric bacterial pathogens.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Dissemination of bacteria following intestinal infection can lead to severe disease, including sepsis, organ damage, and death. However, the intestinal bacterial population dynamics governing the colonization of mucosal and systemic tissues and the intestinal sites that seed systemic spread are not clear.\n                        <jats:italic toggle=\"yes\">Yersinia pseudotuberculosis<\/jats:italic>\n                        is a rodent and human intestinal pathogen closely related to the plague agent and provides a natural rodent-adapted model to study systemic bacterial dissemination. Our findings define the infection dynamics of enteric\n                        <jats:italic toggle=\"yes\">Yersinia<\/jats:italic>\n                        and the impact of the innate immune system on\n                        <jats:italic toggle=\"yes\">Yersinia<\/jats:italic>\n                        colonization of the intestine and systemic organs.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.01779-25","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T13:00:19Z","timestamp":1757422819000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["TNF signaling maintains local restriction of bacterial founder populations in intestinal and systemic sites during oral\n                    <i>Yersinia<\/i>\n                    infection"],"prefix":"10.1128","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-6400","authenticated-orcid":false,"given":"Stefan T.","family":"Peterson","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00b30xv10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine G.","family":"Dailey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04b6nzv94","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Brigham and Women's Hospital","place":["Boston, USA"]},{"name":"Department of Microbiology, Harvard Medical School","place":["Boston, 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