{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:40:32Z","timestamp":1792798832692,"version":"4.5.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Health Innovation Challenge Fund","award":["HICF-T5-342 WT098600"],"award-info":[{"award-number":["HICF-T5-342 WT098600"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["098051"],"award-info":[{"award-number":["098051"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wellcome Trust Training Fellowship","award":["103387\/Z\/13\/Z"],"award-info":[{"award-number":["103387\/Z\/13\/Z"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Wellcome Trust Sir Henry Postdoctoral Fellowship","award":["110243\/Z\/15\/Z"],"award-info":[{"award-number":["110243\/Z\/15\/Z"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2018,12,21]]},"abstract":"<jats:p>\n                    The rise in rates of human infection caused by vancomycin-resistant\n                    <jats:named-content content-type=\"genus-species\">Enterococcus faecium<\/jats:named-content>\n                    (VREfm) strains between 1988 to the 2000s in Europe was suggested to be associated with acquisition from livestock. As a result, the European Union banned the use of the glycopeptide drug avoparcin as a growth promoter in livestock feed. While some studies reported a decrease in VREfm in livestock, others reported no reduction. Here, we report the first livestock VREfm prevalence survey in the UK since 2003 and the first large-scale study using whole-genome sequencing to investigate the relationship between\n                    <jats:named-content content-type=\"genus-species\">E. faecium<\/jats:named-content>\n                    strains in livestock and humans. We found a low prevalence of VREfm in retail meat and limited evidence for recent sharing of strains between livestock and humans with bloodstream infection. There was evidence for limited sharing of genes encoding antibiotic resistance between these reservoirs, a finding which requires further research.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01780-18","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T05:47:27Z","timestamp":1541483247000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":130,"title":["Genomic Surveillance of Enterococcus faecium Reveals Limited Sharing of Strains and Resistance Genes between Livestock and Humans in the United Kingdom"],"prefix":"10.1128","volume":"9","author":[{"given":"Theodore","family":"Gouliouris","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Cambridge, Cambridge, United Kingdom"},{"name":"Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United 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