{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:00:06Z","timestamp":1783605606998,"version":"3.55.0"},"reference-count":119,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI139248"],"award-info":[{"award-number":["AI139248"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI151979"],"award-info":[{"award-number":["AI151979"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI121365"],"award-info":[{"award-number":["AI121365"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:p>Innovative strategies for developing new antimicrobials are needed. Combining our knowledge of host-pathogen interactions and relevant drug characteristics has the potential to reveal new approaches to treating infection.<\/jats:p>","DOI":"10.1128\/mbio.01790-22","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T13:01:32Z","timestamp":1663851692000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes"],"prefix":"10.1128","volume":"13","author":[{"given":"Joseph A.","family":"Villanueva","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Crooks","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni A.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin L. J.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9348-2894","authenticated-orcid":true,"given":"Zachary D.","family":"Dalebroux","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-0876","authenticated-orcid":true,"given":"Corrella S.","family":"Detweiler","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0293-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13664"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14134"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.95.3.833-843.1968"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuv008"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000414"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01369-10"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(01)01490-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2018.10.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009227"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38577-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00410-17"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007115"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01536-19"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009119"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01801-21"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010606"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13598"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.050054"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401283101"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00023"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00642-08"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90295-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.1.4.283"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.10.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00973-07"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.21.6287-6294.2003"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.12.005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00102"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2019.11.008"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0000057"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.rec12295"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-12-1096"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.147.3.820-826.1981"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-022x(85)90045-4"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1097(97)00140-7"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00694-11"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611173113"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(02)00514-X"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14024050"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32077-X"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.171.12.6867-6869.1989"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63798-6"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010427108"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708019200"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316901111"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D026203"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(78)90056-7"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05634.x"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-016-9998-6"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.118.084541"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1997.tb00285.x"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00442-21"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04516-14"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2018.1526531"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftaa057"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftaa056"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020418"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2015.1135289"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01301-09"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073287"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02044-13"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1227-0"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1080\/09687680802187765"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.06.004"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006876"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2012.04.005"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05357"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005485107"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01053-10"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.562094"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.612931"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.5.3240"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.9.1261"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4041-4047.1999"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032514299"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.2.351"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.1.319-325.1996"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01279.x"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0966-842x(98)01324-9"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001518"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.164"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.IJC_364_17"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24020249"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00837"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-409x(00)00129-0"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2017.05.003"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.841-851.2006"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.10.027"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1177\/1751143714564816"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2006.00762.x"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03991.x"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-019-00938-9"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.7.1393"},{"key":"e_1_3_2_96_2","first-page":"218","article-title":"Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives","volume":"9","author":"Van Bambeke F","year":"2006","unstructured":"Van Bambeke F, Barcia-Macay M, Lemaire S, Tulkens PM. 2006. Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives. Curr Opin Drug Discov Devel 9:218\u2013230.","journal-title":"Curr Opin Drug Discov Devel"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113951118"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.05.012"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02612-1"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2020.1822278"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4268"},{"key":"e_1_3_2_102_2","unstructured":"CDC. 2022. Tuberculosis (TB): treatment for TB disease. Centers for Disease Control and Prevention Atlanta GA. https:\/\/www.cdc.gov\/tb\/topic\/treatment\/tbdisease.htm. Accessed 9 March 2022."},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0025-7125(05)70309-6"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315279"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1649-1660.2006"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/291238a0"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02617-21"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.3.595-600.2004"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.62.3.293-300.1951"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-48-13311"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12641"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041510320"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(83)90388-2"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-13-301"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0732-9_11"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(79)90085-3"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7030085"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230767"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-017-2757-8"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36163"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01790-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01790-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T13:21:28Z","timestamp":1666790488000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01790-22"}},"subtitle":[],"editor":[{"given":"Thomas J.","family":"Silhavy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Nina R.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":119,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,26]]}},"alternative-id":["10.1128\/mbio.01790-22"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01790-22","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01790-22"}}