{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:21:13Z","timestamp":1791778873717,"version":"4.3.4"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["U54AG054349"],"award-info":[{"award-number":["U54AG054349"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG00096-38"],"award-info":[{"award-number":["AG00096-38"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,12,20]]},"abstract":"<jats:p>Microorganisms residing within the gastrointestinal tract are implicated in the onset and progression of Alzheimer\u2019s disease (AD) through the mediation of inflammation, exchange of small-molecules across the blood-brain barrier, and stimulation of the vagus nerve. Unfortunately, most animal models for AD are housed under conditions that do not reflect real-world human microbial exposure and do not sufficiently account for (or meaningfully consider) variations in the microbiome.<\/jats:p>","DOI":"10.1128\/mbio.01794-22","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T14:06:49Z","timestamp":1670249209000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer\u2019s Disease"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-5038","authenticated-orcid":true,"given":"Sage J. B.","family":"Dunham","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn A.","family":"McNair","sequence":"additional","affiliation":[{"name":"Department of Computational Science, University of California Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Avelar-Barragan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Forner","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders (UCI MIND), University of California Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-6014","authenticated-orcid":true,"given":"Katrine L.","family":"Whiteson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12362"},{"key":"e_1_3_2_3_2","article-title":"2022 Alzheimer\u2019s disease facts and figures","volume":"18","author":"Alzheimer\u2019s Association","year":"2022","unstructured":"Alzheimer\u2019s Association. 2022. 2022 Alzheimer\u2019s disease facts and figures. Alzheimers Dement 18. https:\/\/www.alz.org\/media\/documents\/alzheimers-facts-and-figures.pdf.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.11.024"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-08243-z"},{"key":"e_1_3_2_7_2","unstructured":"U.S. Food and Drug Administration. (2021 June 07). FDA\u2019s Decision to Approve New Treatment for Alzheimer\u2019s Disease. https:\/\/www.fda.gov\/drugs\/news-events-human-drugs\/fdas-decision-approve-new-treatment-alzheimers-disease."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00540-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12213"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0231-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222313168"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000700"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22624-z"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00153"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161141"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1494-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105314"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118627"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.02.010"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0216-x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182386"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9040815"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep46856"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13601-y"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00632-19"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.217"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-021-01054-y"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.713726"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.05.027"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180678"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0540-4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101556"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3466"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00237"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.11.007"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00261-19"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-017-1052-0"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11319"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-006-0063-1"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-1-r4"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21986-7"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89185-5"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0267-5"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160022"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.05.054"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061196"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72989-2"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.023"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.bvv8n69w"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.004107"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26310-y"},{"key":"e_1_3_2_56_2","volume-title":"R Foundation for Statistical Computing","author":"Zhang Z","year":"2014","unstructured":"Zhang Z, Ersoz E, Lai C-Q, Todhunter RJ, Tiwari HK, Gore M, Bradbury PJ, Yu J, Arnett DK, Ordovas JM, Buckler ES, Cho RJ, Mindrinos M, Richards DR, Sapolsky RJ, Anderson M, Drenkard E, Dewdney J, Reuber TL, Stammers M, Federspiel N, Theologis A, Yang WH, Hubbell E, Au M, Chung EY, Lashkari D, Lemieux B, Dean C, Lipshutz RJ, Ausubel FM, Davis RW, Oefner PJ, Bradbury PJ, Zhang Z, Kroon DE, Casstevens TM, Ramdoss Y, Buckler ES, Glaubitz JC, Casstevens TM, Lu F, Harriman J, Elshire RJ, Sun Q, Buckler ES, Lenn\u00e9 JM, Takan JP, Mgonja MA, Manyasa EO, et al. 2014. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. http:\/\/www.R-project.org\/."},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3"},{"key":"e_1_3_2_58_2","unstructured":"Kolde R. 2019. pheatmap: pretty heatmaps. https:\/\/cran.r-project.org\/web\/packages\/pheatmap\/index.html."},{"key":"e_1_3_2_59_2","unstructured":"Oksanen J Blanchet FG Friendly M Kindt R Legendre P McGlinn D Minchin PR O\u2019Hara RB Simpson GL Solymos P Stevens MHH Szoecs E Wagner H. 2017 vegan: community ecology package. https:\/\/github.com\/vegandevs\/vegan. Accessed on 1 April 2021."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty648"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01794-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01794-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T14:12:19Z","timestamp":1671545539000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01794-22"}},"subtitle":[],"editor":[{"given":"Gary B.","family":"Huffnagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12,20]]}},"alternative-id":["10.1128\/mbio.01794-22"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01794-22","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"2022-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01794-22"}}