{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:47:32Z","timestamp":1791557252984,"version":"4.3.4"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Swiss Research National Foundation","award":["31003A-172958"],"award-info":[{"award-number":["31003A-172958"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,8,25]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles, the drugs used for both first-line treatment and prophylaxis of invasive aspergillosis. In this context, some of the latest antifungals, i.e., echinocandins, have gained attention. Even though acquired resistance to echinocandins is yet uncommon in\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            clinical isolates, some strains exhibit another characteristic that relies on their capacity to grow at suprainhibitory echinocandin concentrations\n            <jats:italic>in vitro<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/mbio.01816-20","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T13:13:56Z","timestamp":1597670036000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus"],"prefix":"10.1128","volume":"11","author":[{"given":"Nicolas","family":"Papon","sequence":"first","affiliation":[{"name":"Host-Pathogen Interaction Study Group (GEIHP, EA 3142), UNIV Angers, Angers, France"},{"name":"Federative Structure of Research Cellular Interactions and Therapeutic Applications, SFR 4208 ICAT, Univ Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-6105","authenticated-orcid":false,"given":"Florent","family":"Morio","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU Nantes, Nantes, France"},{"name":"D\u00e9partement de Parasitologie Et Mycologie M\u00e9dicale, EA1155 IICiMed, Institut de Recherche en Sant\u00e9 2, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-4178","authenticated-orcid":false,"given":"Dominique","family":"Sanglard","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Department of Laboratory, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007964"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2507.181625"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01277-17"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof4010005"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00399-19"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01690-16"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00705-17"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14191-1"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00816-20"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0968-0004(98)01201-8"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0121-1"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01816-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01816-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:19:51Z","timestamp":1646709591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01816-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8,25]]}},"alternative-id":["10.1128\/mBio.01816-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01816-20","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,25]]},"assertion":[{"value":"2020-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01816-20"}}