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The pathogenesis of<jats:named-content content-type=\"genus-species\">C. gattii<\/jats:named-content>is not well understood, but an important characteristic is that<jats:named-content content-type=\"genus-species\">C. gattii<\/jats:named-content>is capable of evading host cell-mediated immune defenses initiated by DCs. Here, we report that when virulent<jats:named-content content-type=\"genus-species\">C. gattii<\/jats:named-content>becomes ingested by a DC, the intracellular compartment containing the fungi is covered by a persistent protein cage structure consisting of F-actin. This F-actin cage acts as a barrier to prevent interaction with other intracellular compartments, and as a result, the DC fails to kill the fungi and activate important cell-mediated immune responses. We propose that this unique immune evasion mechanism permits<jats:named-content content-type=\"genus-species\">C. gattii<\/jats:named-content>to remain unchallenged within host cells, leading to persistent infection.<\/jats:p>","DOI":"10.1128\/mbio.01821-20","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T12:52:04Z","timestamp":1606135924000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Phagosomal F-Actin Retention by Cryptococcus gattii Induces Dendritic Cell Immunoparalysis"],"prefix":"10.1128","volume":"11","author":[{"given":"Khusraw","family":"Jamil","sequence":"first","affiliation":[{"name":"The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, 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Shun","family":"Li","sequence":"additional","affiliation":[{"name":"The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Ogbomo","sequence":"additional","affiliation":[{"name":"The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Olszewski","sequence":"additional","affiliation":[{"name":"VA Ann Arbor Healthcare System, Research Service, Ann Arbor, 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Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402981101"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1910.130441"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir723"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01339-12"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.4049\/jimmunol.144.4.1472","article-title":"Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans","volume":"144","author":"Mody CH","year":"1990","unstructured":"Mody CH, Lipscomb MF, Street NE, Toews GB. 1990. 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