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Ceftazidime-avibactam (CZA) belongs to a new class of broad-spectrum beta-lactam\/beta-lactamase inhibitor combinations designed to treat infections caused by multidrug-resistant bacteria. Understanding the emergence of resistance to this important new drug class is of critical importance. In this work, we demonstrate that evolved mismatch repair deficiency in\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    , an important pathogen responsible for significant morbidity and mortality among hospitalized patients, may facilitate rapid acquisition of resistance to CZA in the context of acute infection. These findings are relevant for both diagnosis and treatment of antimicrobial resistance emerging in acute infection in the hypermutator background and additionally have implications for the emergence of more virulent phenotypes.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01822-19","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T10:13:52Z","timestamp":1568628832000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection"],"prefix":"10.1128","volume":"10","author":[{"given":"Pavel P.","family":"Khil","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA"},{"name":"Laboratory of Clinical Immunology and Microbiology, 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