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However, many healthy women lacking BV symptoms have vaginal microbiomes dominated by microbes associated with BV, resulting in debate about the definition of a healthy vaginal microbiome. Despite substantial evidence that the reproductive health of a woman depends on the vaginal microbiota, future therapies that may improve reproductive health outcomes are stalled due to limited understanding surrounding the ecology of the vaginal microbiome. Here, we use sequencing and metabolomic techniques to show novel associations between vaginal microbes and metabolites during healthy pregnancy. We speculate these associations underlie microbiome dynamics and may contribute to a better understanding of transitions between alternative vaginal microbiome compositions.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01851-20","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T09:12:46Z","timestamp":1598260366000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["Cervicovaginal Microbiome Composition Is Associated with Metabolic Profiles in Healthy Pregnancy"],"prefix":"10.1128","volume":"11","author":[{"given":"Andrew","family":"Oliver","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"LaMere","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Weihe","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Wandro","sequence":"additional","affiliation":[{"name":"Center for Microbiome Innovation, University of California, San Diego, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Development, Health and Disease Research Program, College of Health Sciences, University of California, Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathik D.","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Development, Health and Disease Research Program, College of Health Sciences, University of California, Irvine, Irvine, California, USA"},{"name":"Department of Psychiatry and Human Behavior, College of Health Sciences, University of California, Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, University of California, Davis, Davis, California, USA"},{"name":"Department of Viticulture &amp; Enology, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Pride","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California, San Diego, San Diego, California, USA"},{"name":"Department of Medicine, University of California, San Diego, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Fiehn","sequence":"additional","affiliation":[{"name":"West Coast Metabolomics Center, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trent","family":"Northen","sequence":"additional","affiliation":[{"name":"Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"de Raad","sequence":"additional","affiliation":[{"name":"Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B. 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