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Retroviruses, e.g., HIV-1, can be severe pathogens when they cross species barriers, and bat restrictions corresponding to retroviruses are comparatively unstudied. Here, we compared the abilities of retroviruses from three genera (\n            <jats:italic>Lentivirus<\/jats:italic>\n            ,\n            <jats:italic>Gammaretrovirus<\/jats:italic>\n            , and\n            <jats:italic>Spumavirus<\/jats:italic>\n            ) to infect cells of the large fruit-eating bat\n            <jats:named-content content-type=\"genus-species\">P. alecto<\/jats:named-content>\n            and other mammals. We identified a major, specific postentry restriction to primate lentiviruses. HIV-1 and SIVmac are potently blocked at early life cycle steps, but nonprimate lentiviruses and foamy retroviruses are entirely unrestricted. Despite acting postentry and in a CypA-dependent manner with features reminiscent of antiretroviral factors from other mammals, this restriction was not saturable with virus-like particles and was independent of\n            <jats:named-content content-type=\"genus-species\">P. alecto<\/jats:named-content>\n            TRIM5, TRIM21, TRIM22, TRIM34, and MX2. These results identify a novel restriction and highlight cyclophilin-capsid interactions as ancient species-specific determinants of retroviral infection.\n          <\/jats:p>","DOI":"10.1128\/mbio.01854-20","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T14:36:30Z","timestamp":1600094190000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat"],"prefix":"10.1128","volume":"11","author":[{"given":"James H.","family":"Morrison","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, University of Colorado, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Colorado, Aurora, Colorado, 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