{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:18:47Z","timestamp":1793603927485,"version":"4.5.0"},"reference-count":69,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"The Swedish Research Council","doi-asserted-by":"publisher","award":["2020-02061"],"award-info":[{"award-number":["2020-02061"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bjarne Ahlstr\u00f6m Memorial Fund for Clinical Neurology"},{"DOI":"10.13039\/501100006350","name":"Stiftelsen Clas Groschinskys Minnesfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006350","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HKH The Crown Princess Lovisa Association for Child Care"},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvalls Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010823","name":"Tore Nilsons Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School"},{"DOI":"10.13039\/100012615","name":"University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Program in Health Sciences, University of Southern Santa Catarina"},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARGDNTF-19-619645"],"award-info":[{"award-number":["AARGDNTF-19-619645"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["NIH\/NIA grant 1RF1AG072491"],"award-info":[{"award-number":["NIH\/NIA grant 1RF1AG072491"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020423","name":"Texas Alzheimer's Research and Care Consortium","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020423","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:p>The lack of solute drainage due to a dysfunctional glymphatic system leads to an increase of the neurotoxic bacterial material in the CSF compartments of the brain, ultimately leading to brain-wide neuroinflammation and neuronal damage with consequent impairment of neurological functions. The loss of function of the glymphatic system can therefore be a leading cause of the neurological sequelae developing post-bacterial meningitis.<\/jats:p>","DOI":"10.1128\/mbio.01886-22","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T08:00:24Z","timestamp":1661760024000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis"],"prefix":"10.1128","volume":"13","author":[{"given":"Jaqueline S.","family":"Generoso","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Thorsdottir","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Collodel","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Dominguini","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta R. E.","family":"Santo","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricia","family":"Petronilho","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Barichello","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, Santa Catarina, Brazil"},{"name":"Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-9120","authenticated-orcid":true,"given":"Federico","family":"Iovino","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2015.12.012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198772"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000417"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.04.009"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.01.020"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.11.015"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1692-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00576"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9107-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90603"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26186"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa179"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-021-00102-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40070"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068408"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00873"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4137\/CPath.S40497"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00198"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2006.0157"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109718"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092236"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01099-x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0850-z"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.109"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2021.1883730"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246898"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1160"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-7215-0_9"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.577312"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(84)90167-6"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-03-0183"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-016-0040-3"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.07.001"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.11.008"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.109"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30318-1"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.03.028"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1533-2"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.05.003"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370213508354"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2013.08.001"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161668"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00008-11"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41911"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.698036"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009432"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-2236(00)02024-5"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2014.11.013"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1080\/15622970510030063"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01656"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-279"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-010-8098-4"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20207"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"e_1_3_2_56_2","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"1996","unstructured":"National Research Council. 1996. Guide for the care and use of laboratory animals, 7th ed. National Academies Press, Washington, DC.","edition":"7"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0304-8"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.02.009"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.10.039"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.04.072"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6490652"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1981.240.4.F329"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91275-6"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(83)90050-x"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.06.054"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.02.007"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.09.031"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9068-9_7"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.34600"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84705"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01886-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01886-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T09:20:33Z","timestamp":1666776033000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01886-22"}},"subtitle":[],"editor":[{"given":"N.","family":"Luisa Hiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10,26]]}},"alternative-id":["10.1128\/mbio.01886-22"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01886-22","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.04.14.488283","asserted-by":"object"}]},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01886-22"}}