{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:31:34Z","timestamp":1790922694553,"version":"4.1.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2016,12,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Siderophores are small molecular iron chelators that are produced by microbes and whose most notable function is to sequester iron from the host and provide this essential metal nutrient to microbes. Recent studies have proposed additional, noncanonical roles for siderophores, including the acquisition of noniron metals and modulation of host functions. Recently, Holden et al. (V. I. Holden, P. Breen, S. Houle, C. M. Dozois, and M. A. Bachman, mBio 7:e01397-16, 2016,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1128\/mBio.01397-16\">http:\/\/dx.doi.org\/10.1128\/mBio.01397-16<\/jats:ext-link>\n            ) showed that siderophores secreted by\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            during lung infection induce stabilization of the transcription factor HIF-1\u03b1, increase the expression of proinflammatory cytokines in the lung, and promote dissemination of\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            to the spleen. Thus, their study demonstrated novel roles for siderophores\n            <jats:italic>in vivo<\/jats:italic>\n            , beyond iron sequestration. The interaction of siderophores with host cells further promotes the pathogenicity of\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            and is likely relevant for other pathogens that also secrete siderophores in the host.\n          <\/jats:p>","DOI":"10.1128\/mbio.01906-16","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T23:03:50Z","timestamp":1479337430000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Siderophores: More than Stealing Iron"],"prefix":"10.1128","volume":"7","author":[{"given":"Judith","family":"Behnsen","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, California, USA"},{"name":"Institute for Immunology, University of California Irvine School of Medicine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6487-4215","authenticated-orcid":false,"given":"Manuela","family":"Raffatellu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, California, USA"},{"name":"Institute for Immunology, University of California Irvine School of Medicine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.04.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.2.223-249.2002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0630018100"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03104"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio771"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000622"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.03.011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05114-11"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00224-11"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4mt00333k"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121771"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1020"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12693"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2607"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.12.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01849-14"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01397-16"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01906-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01906-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T02:10:37Z","timestamp":1646705437000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01906-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,30]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12,30]]}},"alternative-id":["10.1128\/mBio.01906-16"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01906-16","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,30]]},"assertion":[{"value":"2016-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01906-16"}}