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Nevertheless, EBV is the causative agent for infectious mononucleosis (IM) and for lymphoproliferative disorders, including Burkitt and Hodgkin lymphomas. The immune system of the infected host is thought to prevent tumor formation in healthy virus carriers. EBV was one of the first viruses described to express miRNAs, and many host and viral targets were identified for these\n                    <jats:italic>in vitro<\/jats:italic>\n                    . However, their role during EBV infection\n                    <jats:italic>in vivo<\/jats:italic>\n                    remained unclear. This work is the first to describe that EBV miRNAs mainly increase viremia and virus-associated lymphomas through dampening antigen recognition by adaptive immune responses in mice with reconstituted immune responses. Currently, there is no prophylactic or therapeutic treatment to restrict IM or EBV-associated malignancies; thus, targeting EBV miRNAs could promote immune responses and limit EBV-associated pathologies.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01941-18","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T07:21:43Z","timestamp":1547450503000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["MicroRNAs of Epstein-Barr Virus Attenuate T-Cell-Mediated Immune Control\n                    <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"10","author":[{"given":"Anita","family":"Murer","sequence":"first","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich, Z\u00fcrich, 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