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Echinocandins are the newest fungicidal drug class introduced but are ineffective in treating cryptococcosis. Our previous study identified the lipid flippase subunit Cdc50 as a contributor to echinocandin resistance in\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            . Here, we further elucidated the mechanism of Cdc50-mediated caspofungin drug resistance. We discovered that Cdc50 interacts with the mechanosensitive calcium channel protein Crm1 to regulate calcium homeostasis and caspofungin resistance via calcium\/calcineurin signaling. These results provide novel insights into echinocandin resistance in this pathogen, which may lead to new treatment options, as well as inform echinocandin resistance mechanisms in other fungal organisms and, hence, advance our understanding of modes of antifungal drug susceptibility and resistance.\n          <\/jats:p>","DOI":"10.1128\/mbio.01952-19","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T11:07:23Z","timestamp":1575889643000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans"],"prefix":"10.1128","volume":"10","author":[{"given":"Chengjun","family":"Cao","sequence":"first","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, 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