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Phosphatases play a major role in cell metabolism and contribute to control the release of P from phosphorylated organic compounds, including phytate. Apart from the relationship with pathogenesis and the enormous economic relevance, phosphatases\/phytases are also important for reduction of phosphorus pollution. Almost all known functional phosphatases\/phytases are derived from cultured individual microorganisms. We demonstrate here for the first time the potential of functional metagenomics to exploit the phosphatase\/phytase pools hidden in environmental soil samples. The recovered diversity of phosphatases\/phytases comprises new types and proteins exhibiting largely unknown characteristics, demonstrating the potential of the screening method for retrieving novel target enzymes. The insights gained into the unknown diversity of genes involved in the P cycle highlight the power of function-based metagenomic screening strategies to study Earth\u2019s phosphatase pools.<\/jats:p>","DOI":"10.1128\/mbio.01966-18","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T11:50:49Z","timestamp":1548676249000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Functional Metagenomics Reveals an Overlooked Diversity and Novel Features of Soil-Derived Bacterial Phosphatases and Phytases"],"prefix":"10.1128","volume":"10","author":[{"given":"Genis Andr\u00e9s","family":"Castillo Villamizar","sequence":"first","affiliation":[{"name":"Department of Genomic and Applied Microbiology and G\u00f6ttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August University, G\u00f6ttingen, Germany"},{"name":"L\u00ednea tecnol\u00f3gica biocorrosi\u00f3n, Corporaci\u00f3n para la investigaci\u00f3n de la corrosi\u00f3n C.I.C. 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