{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:15:00Z","timestamp":1788408900560,"version":"build-2803163510"},"reference-count":120,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001825","name":"Ministry of Science, Innovation and Higher Education | Danish Agency for Science and Higher Education","doi-asserted-by":"publisher","award":["10-083748"],"award-info":[{"award-number":["10-083748"]}],"id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,10,29]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>\n            is one of the most important human pathogens but is closely related to\n            <jats:named-content content-type=\"genus-species\">Streptococcus mitis<\/jats:named-content>\n            , with which humans live in harmony. The fact that the two species evolved from a common ancestor provides a unique basis for studies of both infection-associated properties and properties important for harmonious coexistence with the host. By detailed comparisons of genomes of the two species and other related streptococci, we identified 224 genes associated with virulence and 25 genes unique to the mutualistic species. The exclusive presence of the virulence factors in\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            enhances their potential as vaccine components, as a direct impact on beneficial members of the commensal microbiota can be excluded. Successful adaptation of\n            <jats:named-content content-type=\"genus-species\">S. mitis<\/jats:named-content>\n            and other commensal streptococci to a harmonious relationship with the host relied on genetic stability and properties facilitating life in biofilms.\n          <\/jats:p>","DOI":"10.1128\/mbio.01985-19","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T13:59:04Z","timestamp":1567605544000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Identification of Virulence-Associated Properties by Comparative Genome Analysis of Streptococcus pneumoniae, S. pseudopneumoniae, S. mitis, Three S. oralis Subspecies, and\n            <i>S. infantis<\/i>"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-0472","authenticated-orcid":false,"given":"Mogens","family":"Kilian","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Tettelin","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.001433"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00041-15"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro771"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0001-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2010.00601.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.1.25"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2005.130953"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000573"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.47.100193.000513"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.12.5620-5629.1998"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02335.x"},{"key":"e_1_3_2_13_2","first-page":"1389","article-title":"Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors","volume":"45","author":"Hava DL","year":"2002","unstructured":"Hava DL, Camilli A. 2002. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Mol Microbiol 45:1389\u20131406.","journal-title":"Mol Microbiol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1054-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.10.5582-5596.2004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006582"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01844-16"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.3.1374-1382.2000"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002683"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01746-09"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01490-14"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/516103"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.77"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01511-07"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009426"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3717-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msw054"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msj030"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr652"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-272"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555816537.ch2"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2004.06.019"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00316-06"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061217"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.19.5709-5717.2001"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6055"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01725.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.4.1126-1133.1999"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2012.0026"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2004.10.021"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01821.x-i2"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.7.2545-2554.2002"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1250-1256.2006"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.24.8229-8239.2004"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01442-05"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja110733q"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00303-12"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033320"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-39-4-471"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5817-0_4"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2009.00172.x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2012.00655.x"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06796.x"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.03978.x"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00384-08"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025124"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky469"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.6.3827-3836.2001"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.03.071"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00474-07"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1729-4"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4802-y"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01272-08"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep42976"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1997.tb01004.x"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6186-6192.2001"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00295-12"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198545"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.01.002"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r107"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-7-80"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602404200"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.7138"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1996.tb00724.x"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35921-3"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03199"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/3.Supplement_1.S1"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408419109113510"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.4.1106"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2015.1022507"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01863-18"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01289-13"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6471"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky906"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00044-12"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01419.x"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13045"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02269-16"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.04.002"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2009.00564.x"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00063"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1997.mmi494.x"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.5391899.x"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.5.2526-2534.2002"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01727-06"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802376"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)00071-4"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.821-829.2006"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2012.06.007"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix647"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009435"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02414.x"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.8.4389-4398.2002"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.8.4579-4588.2004"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.039586-0"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01499-16"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1991.tb00466.x"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610226104"},{"key":"e_1_3_2_109_2","first-page":"333","article-title":"Lipoprotein receptors in oral streptococci","volume":"85","author":"Jenkinson HF","year":"1995","unstructured":"Jenkinson HF, McNab R, Loach DM, Tannock GW. 1995. Lipoprotein receptors in oral streptococci. Dev Biol Stand 85:333\u2013341.","journal-title":"Dev Biol Stand"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020031"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01117-10"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00333-17"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065670"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.038299-0"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2017.1307079"},{"key":"e_1_3_2_116_2","first-page":"69","article-title":"Bacteremia following dental extraction and its prophylaxis","volume":"66","author":"Jokinen MA","year":"1970","unstructured":"Jokinen MA. 1970. Bacteremia following dental extraction and its prophylaxis. Suom Hammaslaak Toim 66:69\u2013100.","journal-title":"Suom Hammaslaak Toim"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00924.x"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1990.tb03863.x"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq665"},{"key":"e_1_3_2_120_2","doi-asserted-by":"crossref","unstructured":"Sahl JW Beckstrom-Sternberg SM Babic-Sternberg J Gillece JD Hepp CM Auerbach RK Tembe W Wagner DM Keim PS Pearson T. 2015. The In Silico Genotyper (ISG): an open-source pipeline to rapidly identify and annotate nucleotide variants for comparative genomics applications. bioRxiv doi:10.1101\/015578.","DOI":"10.1101\/015578"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw387"}],"updated-by":[{"DOI":"10.1128\/mbio.02520-19","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000}}],"container-title":["mBio"],"original-title":[],"contributor":[{"given":"Marco","family":"Oggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Carlos","family":"Orihuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01985-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01985-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:05:24Z","timestamp":1646708724000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01985-19"}},"subtitle":[],"editor":[{"given":"N.","family":"Luisa Hiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":120,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10,29]]}},"alternative-id":["10.1128\/mBio.01985-19"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01985-19","relation":{"correction":[{"id-type":"doi","id":"10.1128\/mBio.02520-19","asserted-by":"object"}]},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"assertion":[{"value":"2019-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01985-19"}}