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A genome-wide analysis of lncRNAs in HIV-1-infected primary monocyte-derived macrophages (MDMs) was performed, and 1,145 differentially expressed lncRNAs were identified. An lncRNA named<jats:underline>H<\/jats:underline>IV-1-<jats:underline>e<\/jats:underline>nh<jats:underline>a<\/jats:underline>nced<jats:underline>l<\/jats:underline>ncRNA (<jats:italic>HEAL<\/jats:italic>) is upregulated by HIV-1 infection and promotes HIV replication in T cells and macrophages.<jats:italic>HEAL<\/jats:italic>forms a complex with the RNA-binding protein FUS to enhance transcriptional coactivator p300 recruitment to the HIV promoter. Furthermore,<jats:italic>HEAL<\/jats:italic>knockdown and knockout prevent HIV-1 recrudescence in T cells and microglia upon cessation of azidothymidine treatment, suggesting<jats:italic>HEAL<\/jats:italic>as a potential therapeutic target to cure HIV-1\/AIDS.<\/jats:p>","DOI":"10.1128\/mbio.02016-19","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T11:35:22Z","timestamp":1569238522000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["The Long Noncoding RNA<i>HEAL<\/i>Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter"],"prefix":"10.1128","volume":"10","author":[{"given":"Ti-Chun","family":"Chao","sequence":"first","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghan","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi Kant","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qin","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Yau","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gatikrushna","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kungyen","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Kaul","sequence":"additional","affiliation":[{"name":"Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA"},{"name":"School of Medicine, Division of Biomedical Sciences, University of California, Riverside, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maile Ann Young","family":"Karris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, UCSD Center for AIDS Research, Department of Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq M.","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Pediatrics, UCSD Center for AIDS Research, and Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"UNAIDS. 2019. 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