{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:44:49Z","timestamp":1775321089610,"version":"3.50.1"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["WT108082AIA"],"award-info":[{"award-number":["WT108082AIA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,12,22]]},"abstract":"<jats:p>\n                    Protease inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought to explore the role of mutations in\n                    <jats:italic>gag<\/jats:italic>\n                    -\n                    <jats:italic>pro<\/jats:italic>\n                    genotypic and phenotypic changes in viruses from six Nigerian patients who failed PI-based regimens without known drug resistance-associated protease mutations in order to identify novel determinants of PI resistance.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02036-20","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T08:43:57Z","timestamp":1604306637000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["<i>In Vivo<\/i>\n                    Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix"],"prefix":"10.1128","volume":"11","author":[{"given":"Rawlings","family":"Datir","sequence":"first","affiliation":[{"name":"University College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kemp","sequence":"additional","affiliation":[{"name":"University College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"El Bouzidi","sequence":"additional","affiliation":[{"name":"University College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Mlchocova","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-4672","authenticated-orcid":false,"given":"Richard","family":"Goldstein","sequence":"additional","affiliation":[{"name":"University College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Breuer","sequence":"additional","affiliation":[{"name":"University College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg J.","family":"Towers","sequence":"additional","affiliation":[{"name":"University College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-2281","authenticated-orcid":false,"given":"Clare","family":"Jolly","sequence":"additional","affiliation":[{"name":"University College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel E.","family":"Qui\u00f1ones-Mateu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick S.","family":"Dakum","sequence":"additional","affiliation":[{"name":"Institute for Human Virology, Abuja, Nigeria"},{"name":"Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicaise","family":"Ndembi","sequence":"additional","affiliation":[{"name":"Institute for Human Virology, Abuja, Nigeria"},{"name":"Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-1808","authenticated-orcid":false,"given":"Ravindra K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge, Cambridge, United Kingdom"},{"name":"Africa Health Research Institute, Durban, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70136-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00536-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ556"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61038-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30702-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001810"},{"key":"e_1_3_2_8_2","unstructured":"WHO. 2017. HIV drug resistance report. http:\/\/www.who.int\/hiv\/pub\/drugresistance\/hivdr-report-2017\/en\/. Accessed 1 July 2020."},{"key":"e_1_3_2_9_2","unstructured":"WHO. 2017. Consolidated guidelines on person-centred HIV patient monitoring and case surveillance. http:\/\/www.who.int\/hiv\/pub\/guidelines\/person-centred-hiv-monitoring-guidelines\/en\/. Accessed 1 July 2020."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.06.010"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix015"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328351f5b2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.04.030"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001923"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31820dc0cc"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/386307"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-9-63"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw265"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy589"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01643-08"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820333116"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67399"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11893-8"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25024"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/v2071411"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01211-12"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.06.012"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02682-15"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku296"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137834"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2015.0138"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040036"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000345"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.9.7632-7637.1998"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-9-87"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615342113"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30469-8"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.3099"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1514748112"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108005200"},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","unstructured":"Samsudin F Gan SK-E Bond PJ. 2020. The structural basis for Gag non-cleavage site mutations in determining HIV-1 viral fitness. bioRxiv doi:10.1101\/2020.07.05.188326.","DOI":"10.1101\/2020.07.05.188326"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183243"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01526-19"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2011.0230"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01089"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073582"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz005"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","unstructured":"Goldstein RA Tamuri AU Roy S Breuer J. 2018. Haplotype assignment of virus NGS data using co-variation of variant frequencies. bioRxiv doi:10.1101\/444877.","DOI":"10.1101\/444877"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02356-08"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0b013e3283398216"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msw054"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907075106"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02036-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02036-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:12:33Z","timestamp":1646691153000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02036-20"}},"subtitle":[],"editor":[{"given":"Dimitrios","family":"Paraskevis","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,22]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12,22]]}},"alternative-id":["10.1128\/mBio.02036-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02036-20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/865840","asserted-by":"object"}]},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,22]]},"assertion":[{"value":"2020-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02036-20"}}