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Despite being an exceptionally deadly pathogen,\n                    <jats:named-content content-type=\"genus-species\">B. mandrillaris<\/jats:named-content>\n                    is understudied, leaving many open questions regarding epidemiology, diagnosis, and treatment. Due to the lack of effective drugs to fight\n                    <jats:named-content content-type=\"genus-species\">B. mandrillaris<\/jats:named-content>\n                    infections, mortality rates remain high even for patients receiving intensive care. This report addresses the need for new treatment options through a drug repurposing screen to identify novel\n                    <jats:named-content content-type=\"genus-species\">B. mandrillaris<\/jats:named-content>\n                    inhibitors. The most promising candidate identified was the quinoline antibiotic nitroxoline, which has a long history of safe use in humans. We show that nitroxoline kills\n                    <jats:named-content content-type=\"genus-species\">B. mandrillaris<\/jats:named-content>\n                    at pharmacologically relevant concentrations and exhibits greater potency and selectivity than drugs commonly used in the current standard of care. The findings that we present demonstrate the potential of nitroxoline to be an important new tool in the treatment of life-threatening\n                    <jats:named-content content-type=\"genus-species\">B. mandrillaris<\/jats:named-content>\n                    infections.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02051-18","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T08:59:06Z","timestamp":1540803546000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":67,"title":["Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen\n                    <i>Balamuthia mandrillaris<\/i>"],"prefix":"10.1128","volume":"9","author":[{"given":"Matthew T.","family":"Laurie","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corin V.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA"},{"name":"California State University Monterey Bay, Seaside, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Retallack","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Moser","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy A.","family":"Sakanari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Ang","sequence":"additional","affiliation":[{"name":"Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wilson","sequence":"additional","affiliation":[{"name":"Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle R.","family":"Arkin","sequence":"additional","affiliation":[{"name":"Small Molecule Discovery Center, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4611-9205","authenticated-orcid":false,"given":"Joseph L.","family":"DeRisi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA"},{"name":"Chan Zuckerberg Biohub, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/597260"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00232.x"},{"key":"e_1_3_3_4_2","volume-title":"Pathogenic and Opportunistic Free-Living Amebae Manual of Clinical Microbiology","author":"Visvesvara GS","year":"2011","unstructured":"Visvesvara GS. 2011. 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