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To combat resistant\n            <jats:italic>A. baumannii<\/jats:italic>\n            infections, we need to identify promising therapeutic targets and effective antibiotic combinations. In this study, we comprehensively characterize the genes and pathways that are critical for\n            <jats:italic>A. baumannii<\/jats:italic>\n            viability. We show that genes involved in aerobic metabolism are central to\n            <jats:italic>A. baumannii<\/jats:italic>\n            physiology and may represent appealing drug targets. We also find antibiotic-gene interactions that may impact the efficacy of carbapenems, rifamycins, and polymyxins, providing a new window into how these antibiotics function in mono- and combination therapies. Our studies offer a useful approach for characterizing interactions between drugs and essential genes in pathogens to inform future therapies.\n          <\/jats:p>","DOI":"10.1128\/mbio.02051-23","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T14:00:54Z","timestamp":1703167254000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Essential gene knockdowns reveal genetic vulnerabilities and antibiotic sensitivities in\n            <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9537-2461","authenticated-orcid":false,"given":"Ryan D.","family":"Ward","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA"},{"name":"Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, 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