{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:55:44Z","timestamp":1791550544096,"version":"4.3.4"},"reference-count":67,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/AuthorWarrantyLicense.v1"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX003741"],"award-info":[{"award-number":["I01 BX003741"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F30 AI140611"],"award-info":[{"award-number":["F30 AI140611"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,10,27]]},"abstract":"<jats:p>\n                    Carbapenem-resistant\n                    <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n                    is an urgent public health threat that causes life-threatening infections in immunocompromised hosts. Its resistance to nearly all antibiotics necessitates novel strategies to treat it, including the use of monoclonal antibodies. Monoclonal antibodies are emerging as important adjuncts to traditional pharmaceuticals, and studying how they protect against specific bacteria such as\n                    <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n                    is crucial to their development as effective therapies. Antibody subclass is often overlooked but is a major factor in how an antibody interacts with other mediators of immunity. This paper is the first to examine how the subclass of anticapsular monoclonal antibodies can affect efficacy against CR-\n                    <jats:italic>Kp<\/jats:italic>\n                    . Additionally, this work sheds light on the viability of monoclonal antibody therapy in neutropenic patients, who are most vulnerable to CR-\n                    <jats:italic>Kp<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02059-20","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T09:23:16Z","timestamp":1599470596000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae"],"prefix":"10.1128","volume":"11","author":[{"given":"Michael P.","family":"Motley","sequence":"first","affiliation":[{"name":"Department of Medicine, Infectious Disease Division, Stony Brook University, Stony Brook, New York, USA"},{"name":"Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Diago-Navarro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Division, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasturi","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Division, Stony Brook University, Stony Brook, New York, USA"},{"name":"Veteran\u2019s Administration Medical Center, Northport, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Inzerillo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Division, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina C.","family":"Fries","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Division, Stony Brook University, Stony Brook, New York, USA"},{"name":"Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA"},{"name":"Veteran\u2019s Administration Medical Center, Northport, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1802256"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2019.1703531"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00397-17"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.03.255"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.106"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2206"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.404483"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003306"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200024109"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.2132"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.3.1057-1062.1998"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01007-14"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30755-8"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01005-18"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00297-18"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.08.004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02223-7"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306801"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2297-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321364111"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170884"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu157"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02349-16"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evv062"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00678-15"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00456-16"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02994-19"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.017"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-625343"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.01.005"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03411.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902752"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1176655"},{"key":"e_1_3_3_35_2","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.4049\/jimmunol.154.4.1810","article-title":"Isotype switching from IgG3 to IgG1 converts a nonprotective murine antibody to Cryptococcus neoformans into a protective antibody","volume":"154","author":"Yuan R","year":"1995","unstructured":"Yuan R, Casadevall A, Spira G, Scharff MD. 1995. Isotype switching from IgG3 to IgG1 converts a nonprotective murine antibody to Cryptococcus neoformans into a protective antibody. J Immunol 154:1810\u20131816.","journal-title":"J Immunol"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.60.11.4534-4541.1992"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201700964"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401351101"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.1.151"},{"key":"e_1_3_3_40_2","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.146.8.2659","article-title":"H chain C domains influence the strength of binding of IgG for streptococcal group A carbohydrate","volume":"146","author":"Cooper LJ","year":"1991","unstructured":"Cooper LJ, Schimenti JC, Glass DD, Greenspan NS. 1991. H chain C domains influence the strength of binding of IgG for streptococcal group A carbohydrate. J Immunol 146:2659\u20132663.","journal-title":"J Immunol"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep30938"},{"key":"e_1_3_3_42_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4049\/jimmunol.138.1.285","article-title":"Interaction of IgG3 anti-streptococcal group A carbohydrate (GAC) antibody with streptococcal group A vaccine: enhancing and inhibiting effects of anti-GAC, anti-isotypic, and anti-idiotypic antibodies","volume":"138","author":"Greenspan NS","year":"1987","unstructured":"Greenspan NS, Monafo WJ, Davie JM. 1987. Interaction of IgG3 anti-streptococcal group A carbohydrate (GAC) antibody with streptococcal group A vaccine: enhancing and inhibiting effects of anti-GAC, anti-isotypic, and anti-idiotypic antibodies. J Immunol 138:285\u2013292.","journal-title":"J Immunol"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3134"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02533-16"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01096"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111212"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00958"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw001"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701795"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12466"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2017.09.012"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1214-5"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.12.002"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.5.1962-1967.1998"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00216.2001"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006696"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw443"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.4.519"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.25.3.4424"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.7.4245-4252.2005"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.5.2899-2906.2004"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01075-08"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00300-18"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2000.13.11.1243"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.71"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.212407"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015263"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.55.1.35"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02059-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02059-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:15:11Z","timestamp":1696619711000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02059-20"}},"subtitle":[],"editor":[{"given":"Victor J.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10,27]]}},"alternative-id":["10.1128\/mBio.02059-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02059-20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.24.220780","asserted-by":"object"}]},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"2020-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02059-20"}}