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As members of the Alveolata superphylum, these protozoans possess specialized organelles in addition to those found in all members of the eukaryotic kingdom. Vesicular trafficking is the major route of communication between membranous organelles. Neither the molecular mechanism that allows communication between organelles nor the vesicular fusion events that underlie it are completely understood in Apicomplexa. Here, we assessed the function of SEC1\/Munc18 and SNARE proteins to identify factors involved in the trafficking of vesicles between these various organelles. We show that SEC1\/Munc18 in interaction with SNARE proteins allows targeting of vesicles to the inner membrane complex, prerhoptries, micronemes, apicoplast, and vacuolar compartment from the endoplasmic reticulum, Golgi apparatus, or endosomal-like compartment. These data provide an exciting look at the \u201cZIP code\u201d of vesicular trafficking in apicomplexans, essential for precise organelle biogenesis, homeostasis, and inheritance.<\/jats:p>","DOI":"10.1128\/mbio.02092-20","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T15:39:15Z","timestamp":1603121955000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1\/Munc18 and SNARE Proteins"],"prefix":"10.1128","volume":"11","author":[{"given":"Hugo","family":"Bisio","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Medicine, CMU, Faculty of Medicine, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouaa Ben","family":"Chaabene","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Medicine, 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