{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:34:19Z","timestamp":1793388859146,"version":"4.5.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["19A3001"],"award-info":[{"award-number":["19A3001"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20fk0108257"],"award-info":[{"award-number":["20fk0108257"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:p>SARS-CoV-2 is responsible for the devastating COVID-19 pandemic. Therefore, it is imperative that we learn as much as we can about the biochemistry of the coronavirus proteins to inform development of therapy.<\/jats:p>","DOI":"10.1128\/mbio.02094-21","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T04:32:02Z","timestamp":1629174722000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-7007","authenticated-orcid":true,"given":"David A.","family":"Davis","sequence":"first","affiliation":[{"name":"HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0262-6296","authenticated-orcid":true,"given":"Haydar","family":"Bulut","sequence":"additional","affiliation":[{"name":"HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabha","family":"Shrestha","sequence":"additional","affiliation":[{"name":"HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amulya","family":"Yaparla","sequence":"additional","affiliation":[{"name":"HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah K.","family":"Jaeger","sequence":"additional","affiliation":[{"name":"HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichiro","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Wingfield","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-6334","authenticated-orcid":true,"given":"John J.","family":"Mieyal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Mitsuya","sequence":"additional","affiliation":[{"name":"HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA"},{"name":"Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3057-1395","authenticated-orcid":true,"given":"Robert","family":"Yarchoan","sequence":"additional","affiliation":[{"name":"HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2223-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01833-20"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802606776287090"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1034-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085658"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb3405"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02680-07"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.5.3319-3325.2003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi951525k"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3460305"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.2.1156-1164.1999"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20082068"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.41.25935"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(02)48643-0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.05.022"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506412200"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.043"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000930"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10930-020-09935-8"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S1016-8478(23)17590-X","article-title":"Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases","volume":"25","author":"Shelton MD","year":"2008","unstructured":"Shelton MD, Mieyal JJ . 2008. Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases. Mol Cells 25:332\u2013346.","journal-title":"Mol Cells"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi036022q"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.11.102"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409239109081719"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.02.026"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.9.4170"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4454"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2089"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.143685"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.828426"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20261"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1360"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1334"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.6b00631"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.5.2700"},{"key":"e_1_3_3_36_2","doi-asserted-by":"crossref","unstructured":"Resnick SJ Iketani S Hong SJ Zask A Liu H Kim S Melore S Nair MS Huang Y Tay NES Rovis T Yang HW Stockwell BR Ho DD Chavez A . 29 August 2020. A simplified cell-based assay to identify coronavirus 3CL protease inhibitors. bioRxiv https:\/\/doi.org\/10.1101\/2020.08.29.272864.","DOI":"10.1101\/2020.08.29.272864"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-118414"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07576.x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013595"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251460998"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.04.009"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0820-9"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00026"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2006.11.015"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-019-01013-y"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/cz\/zoy039"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20900-6"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115860"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.12.005"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2021.1857726"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.616341"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf7945"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.10.091"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02094-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02094-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T13:23:20Z","timestamp":1725629000000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02094-21"}},"subtitle":[],"editor":[{"given":"Blossom","family":"Damania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8,31]]}},"alternative-id":["10.1128\/mBio.02094-21"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02094-21","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.04.09.439169","asserted-by":"object"}]},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]},"assertion":[{"value":"2021-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02094-21"}}