{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:41:00Z","timestamp":1790714460392,"version":"4.1.0"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-CE17-0001"],"award-info":[{"award-number":["ANR-17-CE17-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,12,22]]},"abstract":"<jats:p>\n            Cerebral malaria pathophysiology remains unknown despite extensive research. PfEMP1 proteins have been identified as the main\n            <jats:italic>Plasmodium<\/jats:italic>\n            antigen involved in cerebrovascular endothelium sequestration, but it is unclear which\n            <jats:italic>var<\/jats:italic>\n            gene domain is involved in\n            <jats:italic>Plasmodium<\/jats:italic>\n            cytoadhesion. EPCR binding is a major determinant of cerebral malaria whereas the ICAM-1-binding role is still questioned. Our study confirmed the EPCR-binding role in CM pathophysiology with a major overexpression of EPCR-binding domains in CM isolates. In contrast, ICAM-1-binding involvement appears less obvious with A-type ICAM-1-binding and dual receptor-binding domain expression in both CM and UM isolates. We did not find any variations in ICAM-1-binding motif sequences in CM compared to UM isolates. UM and CM patients infected with isolates expressing the ICAM-1-binding motif displayed similar IgG levels against DBL\u03b23 recombinant protein. Our study raises interrogations about the role of these domains in CM physiopathology and questions their use in vaccine strategies against cerebral malaria.\n          <\/jats:p>","DOI":"10.1128\/mbio.02103-20","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T13:59:50Z","timestamp":1605535190000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["PfEMP1 A-Type ICAM-1-Binding Domains Are Not Associated with Cerebral Malaria in Beninese Children"],"prefix":"10.1128","volume":"11","author":[{"given":"V.","family":"Joste","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Guillochon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fraering","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vianou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"},{"name":"Institut de Recherche Clinique du B\u00e9nin (IRCB), Cotonou, B\u00e9nin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Watier","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Inserm, UVSQ, Institut Pasteur, Universit\u00e9 Paris-Saclay, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jafari-Guemouri","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Houz\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, Paris, France"},{"name":"Parasitology Laboratory, Bichat-Claude Bernard hospital, Paris, France"},{"name":"Malaria National Reference Center, Bichat-Claude Bernard hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-4972","authenticated-orcid":false,"given":"A.","family":"Aubouy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse, PHARMADEV, IRD, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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